2. Apoptosis Anti-infection
  3. Apoptosis Antibiotic
  4. Dacarbazine citrate

Dacarbazine citrate  (Synonyms: 达卡巴嗪(柠檬酸); Imidazole Carboxamide citrate)

目录号: HY-B0078A
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Dacarbazine citrate 是一种细胞周期非特异性抗肿瘤烷基化剂。Dacarbazine citrate 抑制 T 和 B 淋巴细胞反应，IC50 分别为 50 和 10 μg/mL。Dacarbazine citrate 可用于凋亡和多种癌症如转移性恶性黑色素瘤的研究。

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Dacarbazine citrate Chemical Structure

Dacarbazine citrate Chemical Structure

CAS No. : 64038-56-8

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Dacarbazine citrate 的其他形式现货产品:

Dacarbazine citrate 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma[1][2].

体外研究
(In Vitro)

Dacarbazine citrate has less pronounced inhibition of mitogenesis with IC50 values of 50 and 10 μg/mL for T and B cells, respectively[2].
Dacarbazine citrate (30 μM, 0-14 min) evokes a concentration-dependent calcium response in hTRPA1-HEK293 cells with an EC50 value of 23 μM and selectively activates the human TRPA1 channel[3].
Dacarbazine citrate (100-10,000 μM, 24 h) has cytotoxic action on B16-F10 melanoma cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dacarbazine citrate 相关抗体:

Cell Viability Assay[3]

Cell Line: B16-F10 cell
Concentration: 100-10,000 μM
Incubation Time: 24 h
Result: Reduced cell viability to 3,000 and 10,000 uM, with an inhibition percentage of 62 ± 2% after 24 h of incubation.
体内研究
(In Vivo)

Dacarbazine citrate (1 mg/kg, i.p.) evokes a concentration-dependent calcium response and the maximum calcium response with an EC50 value of 16 μM in a subset of cells of cultured mouse DRG neurons and excites TRPA1 in rodent sensory neurons[3].
Dacarbazine citrate (1 mg/kg, i.p.; 1, 3, 5 and 7 days for chronic pain or 1 mg/kg, i.p. for acute treatment) induces mechanical and cold allodynia in mice[3].
Dacarbazine citrate-induced nociception can be reduced by TRPA1-deficient mice and antisense oligonucleotide for the TRPA1 receptor[3].
Dacarbazine citrate-induced chronic nociception can be reduced by selective TRPA1 receptor antagonists and antioxidants[3].
Dacarbazine citrate-induced nociception can be resisted by RPA1 antagonist or an antioxidant in a tumor-associated cancer pain model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6, Trpa1+/+ or Trpa1−/− mice[3]
Dosage: 1 mg/kg
Administration: 1 mg/kg, i.p. (for acute treatment); 1 mg/kg, i.p.; 1, 3, 5 and 7 days (for chronic pain)
Result: Caused mechanical allodynia with acute or repeated administration.
Clinical Trial
分子量

374.31

Formula

C12H18N6O8
CAS 号
中文名称

达卡巴嗪(柠檬酸)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dacarbazine citrate 相关分类

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dacarbazine64038-56-8Imidazole Carboxamide达卡巴嗪(柠檬酸)ApoptosisAntibioticcell cycleantineoplasticalkylating agentT lymphoblasticB lymphoblasticmetastatic malignant melanomacancerInhibitorinhibitorinhibit

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