2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Darglitazone

Darglitazone  (Synonyms: CP-86325)

目录号: HY-120160 纯度: 98.15%
COA 产品使用指南

摩尔计算器

Darglitazone (CP-86325)，一种噻唑烷二酮，是一种有效的，选择性的和具有口服活性的 PPAR-γ 激动剂。Darglitazone 有效控制血糖和脂质代谢，可用于 II 型糖尿病研究。

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Darglitazone Chemical Structure

Darglitazone Chemical Structure

CAS No. : 141200-24-0

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规格 价格 是否有货 数量
1 mg ￥350
In-stock
5 mg ￥780
In-stock
10 mg ￥1250
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Darglitazone:

Darglitazone 相关抗体

Top Publications Citing Use of Products

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally active PPAR-γ agonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research[1].

IC50 & Target[1]

PPAR-γ

 

体外研究
(In Vitro)

In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), within 4 h of exposing these cells to 30 μM Darglitazone, there is an increase in uncoupling protein 2 (UCP2) mRNA which reached a plateau of 5-10 times the basal in about 8 h. Darglitazone can stimulate the expression of UCP2 gene probably via PPAR-γ[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Darglitazone 相关抗体:
体内研究
(In Vivo)

Darglitazone treatment restores euglycemia and normalized elevated corticosterone, triglycerides, and very-low-density lipoprotein levels. Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24 h of recovery. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male diabetic ob/ob mice[1]
Dosage: 1 mg/kg
Administration: Oral administration; daily; for 7 days
Result: Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice.
分子量

420.48

Formula

C23H20N2O4S
CAS 号
性状

固体

颜色

White to light yellow

中文名称

达格列酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (118.91 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3782 mL 11.8912 mL 23.7823 mL
5 mM 0.4756 mL 2.3782 mL 4.7565 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.19%

COA (191 KB) RP-HPLC (86 KB)

产品使用指南 (1538 KB)
参考文献

Darglitazone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3782 mL 11.8912 mL 23.7823 mL 59.4559 mL
5 mM 0.4756 mL 2.3782 mL 4.7565 mL 11.8912 mL
10 mM 0.2378 mL 1.1891 mL 2.3782 mL 5.9456 mL
15 mM 0.1585 mL 0.7927 mL 1.5855 mL 3.9637 mL
20 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
25 mM 0.0951 mL 0.4756 mL 0.9513 mL 2.3782 mL
30 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.9819 mL
40 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
50 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1891 mL
60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
80 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5946 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Darglitazone141200-24-0CP-86325达格列酮CP86325CP 86325PPARPeroxisome proliferator-activated receptorsDiabetesthiazolidinedionePPAR-γoralUCP2corticosteroneInhibitorinhibitorinhibit

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