Eflornithine hydrochloride (Synonyms: 盐酸依氟鸟氨酸；依氟鸟氨酸; DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride)

目录号: HY-B0744A 纯度: ≥98.0%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Eflornithine hydrochloride (DFMO hydrochloride) 是酶鸟氨酸脱羧酶的特异性不可逆抑制剂。Eflornithine hydrochloride (DFMO hydrochloride) 可用于非洲锥虫病和女性面部毛发过度生长的研究。

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Eflornithine hydrochloride Chemical Structure

CAS No. : 68278-23-9

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100 mg	￥500	In-stock
500 mg	￥1500	In-stock
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5 g		询价

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Other Forms of Eflornithine hydrochloride:

L-Eflornithine monohydrochloride In-stock
Eflornithine In-stock
Eflornithine hydrochloride hydrate In-stock
L-Eflornithine 询价

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

IC₅₀ & Target

Trypanosoma

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
J774	IC₅₀	> 1000 μM Compound: S3	Cytotoxicity against J774.1 cell line after 48 hrs Cytotoxicity against J774.1 cell line after 48 hrs	[PMID: 16516467]

体内研究
(In Vivo)

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases^[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism^[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles^[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

218.63

Formula

C₆H₁₃ClF₂N₂O₂

CAS 号

68278-23-9

性状

固体

颜色

White to light yellow

中文名称

盐酸依氟乌氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

细胞实验：

H₂O 中的溶解度 : 100 mg/mL (457.39 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5739 mL	22.8697 mL	45.7394 mL
5 mM	0.9148 mL	4.5739 mL	9.1479 mL
10 mM	0.4574 mL	2.2870 mL	4.5739 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (602 KB) SDS (393 KB)

COA (285 KB) HNMR (166 KB) MS (72 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [Content Brief]

[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [Content Brief]

[3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [Content Brief]

[4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. [Content Brief]

Animal Administration ^[3]	Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [Content Brief] [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [Content Brief] [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [Content Brief] [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. [Content Brief]

Animal Administration
^[3]

Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [Content Brief]

[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [Content Brief]

[3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [Content Brief]

[4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. [Content Brief]

Eflornithine hydrochloride 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.5739 mL	22.8697 mL	45.7394 mL	114.3484 mL
	5 mM	0.9148 mL	4.5739 mL	9.1479 mL	22.8697 mL
	10 mM	0.4574 mL	2.2870 mL	4.5739 mL	11.4348 mL
	15 mM	0.3049 mL	1.5246 mL	3.0493 mL	7.6232 mL
	20 mM	0.2287 mL	1.1435 mL	2.2870 mL	5.7174 mL
	25 mM	0.1830 mL	0.9148 mL	1.8296 mL	4.5739 mL
	30 mM	0.1525 mL	0.7623 mL	1.5246 mL	3.8116 mL
	40 mM	0.1143 mL	0.5717 mL	1.1435 mL	2.8587 mL
	50 mM	0.0915 mL	0.4574 mL	0.9148 mL	2.2870 mL
	60 mM	0.0762 mL	0.3812 mL	0.7623 mL	1.9058 mL
	80 mM	0.0572 mL	0.2859 mL	0.5717 mL	1.4294 mL
	100 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1435 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eflornithine68278-23-9DFMOMDL71782RMI71782α-difluoromethylornithine盐酸依氟乌氨酸MDL 71782MDL-71782RMI 71782RMI-71782ParasiteInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Eflornithine hydrochloride (Synonyms: 盐酸依氟鸟氨酸；依氟鸟氨酸; DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride)

Other Forms of Eflornithine hydrochloride:

MCE 顾客使用本产品发表的 10 篇科研文献