2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage
  3. EGFR CDK
  4. EGFR/CDK2-IN-1

EGFR/CDK2-IN-1 (化合物 3b) 是一种 EGFR/CDK2 抑制剂。EGFR/CDK2-IN-1 对 MCF7 和 HepG2 细胞显示出较强的细胞毒性。EGFR/CDK2-IN-1 可用于癌症的研究。

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EGFR/CDK2-IN-1 Chemical Structure

EGFR/CDK2-IN-1 Chemical Structure

CAS No. : 2841405-96-5

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EGFR/CDK2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/CDK2-IN-1 (Compound 3b) is an EGFR/CDK2 inhibitor. EGFR/CDK2-IN-1 shows good cytotoxicity against MCF7 and HepG2 cells. EGFR/CDK2-IN-1 can be used in cancer research[1].

IC50 & Target

EGFR, CDK-2[1].
体外研究
(In Vitro)

EGFR/CDK2-IN-1 (0-20 μM; 48 h) shows excellent activity in both MCF7 and HepG2 with IC50 values of 4.1 and 3.5 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR/CDK2-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF7, HepG2 cells
Concentration: 0-20 μM
Incubation Time: 48 h
Result: Exhibited good cytotoxic activity in breast and liver cancer cells.
分子量

387.65

Formula

C19H12BrClO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR/CDK2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/CDK2-IN-12841405-96-5EGFRCDKEpidermal growth factor receptorErbB-1HER1Cyclin dependent kinasecancerMCF7HepG2Inhibitorinhibitorinhibit

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