2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Apoptosis EGFR
  4. EGFR-IN-47

EGFR-IN-47 是一种有效的且具有口服活性的 EGFRL858R/T790M/C797S 抑制剂，其 IC50 值为 0.01 μM。EGFR-IN-47 诱导细胞周期停滞和细胞凋亡 (apoptosis)。EGFR-IN-47 具有 NSCLC 的研究潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

EGFR-IN-47 Chemical Structure

EGFR-IN-47 Chemical Structure

CAS No. : 3034649-73-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥2400
In-stock
10 mg ￥3840
In-stock
25 mg 现货 询价
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

EGFR-IN-47 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-47 is a potent and orally active EGFRL858R/T790M/C797S inhibitor with an IC50 of 0.01 μM. EGFR-IN-47 induces cell cycle attest and cell apoptosis. EGFR-IN-47 has the potential for the research of NSCLC[1].

IC50 & Target[1]

EGFRL858R/T790M/C797S

0.07 μM (IC50)

体外研究
(In Vitro)

EGFR-IN-47 (compound 14aj) (72 h) shows anti-proliferative effects with IC50s of 0.013 μM, 2.972 μM, 1.031 μM for PC-9 (EGFRL858R/T790M/C797S), A432, A549 cells, respectively[1].
EGFR-IN-47 (0.01, 0.05, 0.25, 1 μM; 24 h) induces cell cycle attest at the G0/G1-phase[1].
EGFR-IN-47 (0.01, 0.05, 0.25 μM) induces cell deathvia apoptosis in a concentration-dependent manner[1].
EGFR-IN-47 (0.01, 0.05, 0.25, 1 μM) inhibits phosphorylation of the EGFR downstream mediators[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-47 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: PC-9 (EGFRL858R/T790M/C797S), A432, A549 cells
Concentration:
Incubation Time: 72 h
Result: Showed anti-proliferative effects with IC50s of 0.013 µM, 2.972 µM, 1.031 µM for PC-9 (EGFRL858R/T790M/C797S), A432, A549 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: PC-9 EGFRL858R/T790M/C797S cells
Concentration: 0.01, 0.05, 0.25, 1 µM
Incubation Time: 24 h
Result: Cells were arrest at the G0/G1-phase.

Apoptosis Analysis[1]

Cell Line: PC-9 EGFRL858R/T790M/C797S cells
Concentration: 0.01, 0.05, 0.25 µM
Incubation Time: 24 h
Result: Induced cell deathvia apoptosis in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: PC-9 EGFRL858R/T790M/C797S cells
Concentration: 0.01, 0.05, 0.25, 1 µM
Incubation Time:
Result: Inhibited phosphorylation of the EGFR downstream mediators.
体内研究
(In Vivo)

EGFR-IN-47 (10, 20, 40 mg/kg; i.g.) shows anti-tumor effect with low toxicity[1].
EGFR-IN-47 (20 mg/kg for i.v.; 20 mg/kg for p.o.) shows an ideal oral bioavailability of 66.05%[1].
Pharmacokinetic Parameters of JAK1/TYK2-IN-2 in Male Sprague-Dawley rats[1].

parameter iv (20 mg/kg) po (20 mg/kg)
AUC0-∞ (mg/Lh) 15.889 10.494
Cmax (mg/L) 6.845 0.77
Tmax (h) 0.083 6
F (%) 66.05
MRT0-∞ (h) 16.439 16.791
Vss (L/kg) 16.015 28.101
CL (L/h/kg) 1.272 2.151
t(1/2) (h) 8.922 11.154
Male Sprague-Dawley rats; 20 mg/kg for i.v.; 20 mg/kg for p.o.[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, BALB/c nude mice (PC-9 EGFRL858R/T790M/C797S cells )[1]
Dosage: 10, 20, 40 mg/kg (dissolved in 25% (v/v) PEG400 plus 5% DMSO)
Administration: I.g.
Result: Showed anti-tumor effect with low toxicity.
Animal Model: Male Sprague-Dawley rats[1]
Dosage: 20 mg/kg
Administration: I.v.; p.o.
Result: Showed an ideal oral bioavailability of 66.05%.
分子量

481.64

Formula

C29H35N7
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (41.52 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0762 mL 10.3812 mL 20.7624 mL
5 mM 0.4152 mL 2.0762 mL 4.1525 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

EGFR-IN-47 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0762 mL 10.3812 mL 20.7624 mL 51.9060 mL
5 mM 0.4152 mL 2.0762 mL 4.1525 mL 10.3812 mL
10 mM 0.2076 mL 1.0381 mL 2.0762 mL 5.1906 mL
15 mM 0.1384 mL 0.6921 mL 1.3842 mL 3.4604 mL
20 mM 0.1038 mL 0.5191 mL 1.0381 mL 2.5953 mL
25 mM 0.0830 mL 0.4152 mL 0.8305 mL 2.0762 mL
30 mM 0.0692 mL 0.3460 mL 0.6921 mL 1.7302 mL
40 mM 0.0519 mL 0.2595 mL 0.5191 mL 1.2976 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-473034649-73-2ApoptosisEGFREpidermal growth factor receptorErbB-1HER1Low toxicityanti-tumorapoptosisphosphorylationG0/G1-phase,orally activePC-9 EGFRL858R/T790M/C797S cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
EGFR-IN-47
目录号：
HY-143337
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z