2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR T790M/L858R-IN-7

EGFR T790M/L858R-IN-7 (Compound 72) 是一种新型的嘧啶类化合物，可以抑制 T790M 和 L818R 突变的 EGFRL (0.05 μM 达到 93 % 的抑制率)。EGFR T790M/L858R-IN-7 通过特异性地与 EGFR 的激酶域结合，进而抑制其磷酸化活性。

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EGFR T790M/L858R-IN-7 Chemical Structure

EGFR T790M/L858R-IN-7 Chemical Structure

CAS No. : 3032760-90-7

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EGFR T790M/L858R-IN-7 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR T790M/L858R-IN-7 (Compound 72) is a novel pyrimidine compound that inhibits the EGFR T790M and L858R mutation with a high efficacy (93% inhibition rate at 0.05 μM). EGFR T790M/L858R-IN-7 functions by specifically binding to the kinase domain of EGFR, thereby inhibiting its phosphorylation activity[1].

分子量

515.56

Formula

C27H29N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR T790M/L858R-IN-7 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

EGFR T790M/L858R-IN-73032760-90-7EGFREpidermal growth factor receptorErbB-1HER11.EGFR InhibitorCancerKinase InhibitorPhosphorylation BlockerInhibitorinhibitorinhibit

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