2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. JAK FLT3 Apoptosis
  4. Flonoltinib maleate

Flonoltinib maleate 是一种口服有效的双重 JAK2/FLT3 抑制剂，对 JAK2，FLT3，JAK1 和 JAK3 的 IC50 分别为 0.7 nM，4 nM，26 nM 和 39 nM。JAK2/FLT3-IN-1 具有抗癌活性。

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Flonoltinib maleate Chemical Structure

Flonoltinib maleate Chemical Structure

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Flonoltinib maleate 的其他形式现货产品:

Other Forms of Flonoltinib maleate:

Flonoltinib maleate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity[1].

IC50 & Target

JAK1

26 nM (IC50)

JAK2

0.7 nM (IC50)

JAK3

39 nM (IC50)

体外研究
(In Vitro)

Flonoltinib maleate (0.008-1 μM; for 2 hours) 以剂量依赖的方式下调 p-FLT3[1]。
Flonoltinib maleate (5-100 nM; for 2 hours) 对诱导 MV4-11 细胞凋亡有剂量依赖性[1]。
lonoltinib maleate (5-100 nM; for 2 hours) 在 MV4-11 细胞中，100 nM 时 G1/G0 百分比为 85%，强烈诱导细胞周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flonoltinib maleate 相关抗体:

Western Blot Analysis[1]

Cell Line: MV4-11 and SET-2 cells
Concentration: 0.008, 0.04, 0.2, 1 μM
Incubation Time: For 2 hours
Result: Down-regulated p-FLT3 in a dose-dependent manner from 0.008 to 1 μM.

Apoptosis Analysis[1]

Cell Line: MV4-11 and SET-2 cells
Concentration: 5, 10, 50, 100 nM
Incubation Time: For 2 hours
Result: Had a dose-dependent effect on the induction of apoptosis in the MV4-11 cells.

Cell Cycle Analysis[1]

Cell Line: MV4-11 cells
Concentration: 5, 10, 50, 100 nM
Incubation Time: For 2 hours
Result: Induced cell cycle arrest with a G1/G0 percentage of 85% at 100 nM.
体内研究
(In Vivo)

Flonoltinib maleate (30 and 60 mg/kg/day; 口服.; 持续14 天) 具有显著的抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mouse models[1]
Dosage: 30 and 60 mg/kg
Administration: Oral administration; daily; for 14 days
Result: Exhibited significant antitumor effects.
The tumor growth inhibitory rates (TGI) were respective 58% and 93% in the MV4-11-bearing mice model.
分子量

583.65

Formula

C29H38FN7O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flonoltinib maleate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FlonoltinibJAKFLT3ApoptosisJanus kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3orallyanti-cancercyclearrestG1/G0MV4-11Inhibitorinhibitorinhibit

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