2. PROTAC Apoptosis Metabolic Enzyme/Protease
  3. PROTACs Glutathione Peroxidase Ferroptosis
  4. GDCNF-11

GDCNF-11 是一种基于伴侣蛋白 HSP90 的 HIM-PROTAC GPX4 降解剂。GDCNF-11 通过 HSP 90 伴侣复合物促进 GPX4 的泛素化和降解，降低内源性 GPX4 来诱导 HT-1080 细胞铁死亡 (ferroptosis)，DC50 值为 0.08 μM。(粉色：靶蛋白配体 (HY-153748); 蓝色：HSP90 配体 (HY-10212); 黑色：Linker (HY-W169526))

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GDCNF-11 Chemical Structure

GDCNF-11 Chemical Structure

CAS No. : 2991588-80-6

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GDCNF-11 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC50 value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526))[1].

分子量

994.99

Formula

C48H53Cl2N13O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GDCNF-11 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GDCNF-112991588-80-6GDCNF11GDCNF 11PROTACsGlutathione PeroxidaseFerroptosisProtein degradersMolecular chaperonesUbiquitinationHT-1080 cell lineInhibitorinhibitorinhibit

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