2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR Cytochrome P450
  4. Gemfibrozil-d6

Gemfibrozil-d6  (Synonyms: CI-719-d6)

目录号: HY-B0258S
COA 产品使用指南

摩尔计算器

Gemfibrozil-d6 是 Gemfibrozil 的氘代物。Gemfibrozil 是一种 PPAR-α 激活剂，为一种降脂剂；Gemfibrozil 同时是 P450 的非选择性抑制剂，对 CYP2C9，2C19，2C8 和 1A2 的 Ki 值分别为 5.8，24，69 和 82 μM。

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Gemfibrozil-d<sub>6</sub> Chemical Structure

Gemfibrozil-d6 Chemical Structure

CAS No. : 1184986-45-5

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规格 价格 是否有货
1 mg ￥1200
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Other Forms of Gemfibrozil-d6:

Gemfibrozil-d6 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gemfibrozil-d6 is the deuterium labeled Gemfibrozil. Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gemfibrozil-d6 相关抗体:
分子量

256.37

Formula

C15H16D6O3
CAS 号
非标记 CAS

25812-30-0
性状

固体

颜色

Off-white to light yellow

中文名称

吉非罗齐 d6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.00%

COA (193 KB)

产品使用指南 (1538 KB)
参考文献

Gemfibrozil-d6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemfibrozil-d61184986-45-5CI-719-d6吉非罗齐 d6PPARCytochrome P450Peroxisome proliferator-activated receptorsCYPsInhibitorinhibitorinhibit

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