IFITM3 - interferon induced transmembrane protein 3 Gene

中文名称：干扰素诱导跨膜蛋白 3

种属: Homo sapiens

同用名: 1-8U; IP15; DSPA2b

基因 ID: 10410 | 基因类型: protein coding

关于 IFITM3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:319,676-320,860 (from NCBI)

This gene has 27 transcripts (splice variants), 243 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 370.9), placenta (RPKM 358.2) and 25 other tissues.

功能概要

干扰素诱导的跨膜 (IFITM) 蛋白是干扰素诱导的抗病毒蛋白家族。该家族包含五个成员，包括 IFITM1、IFITM2 和 IFITM3，属于 CD225 超家族。该基因编码的蛋白质限制多种病毒病原体进入细胞，例如甲型流感病毒、埃博拉病毒和 Sars-CoV-2。[RefSeq 提供，2021 年 11 月]

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM3 基因产物(1)

mRNA	Protein	Name
NM_021034.3	NP_066362.2	interferon-induced transmembrane protein 3

IFITM3 蛋白结构

CD225

0
100
133 a.a.

蛋白主名

其他名称

interferon-induced transmembrane protein 3

dispanin subfamily A member 2b

IFITM3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IFITM3	Q01628	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
种属内	IFITM3	Q01628	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
种属内	IFITM3	Q01628	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
种属内	IFITM3	Q01628	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	PLP1	Homo sapiens	P60201-2	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
种属内	IFITM3	Q01628	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
种属内	IFITM3	Q01628	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
种属内	IFITM3	Q01628	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
种属内	IFITM3	Q01628	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	IFITM3	Q01628	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	IFITM3	Q01628	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
种属内	IFITM3	Q01628	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
种属内	IFITM3	Q01628	LYPD5	Homo sapiens	Q6UWN5	Validated Y2H	32296183
种属内	IFITM3	Q01628	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
种属内	IFITM3	Q01628	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	ELOVL2	Homo sapiens	Q9NXB9	Y2H Array	32296183
种属内	IFITM3	Q01628	ELOVL2	Homo sapiens	Q9NXB9	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	ELOVL2	Homo sapiens	Q9NXB9	Validated Y2H	32296183
种属内	IFITM3	Q01628	SLC10A2	Homo sapiens	Q12908	Validated Y2H	32296183
种属内	IFITM3	Q01628	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
种属内	IFITM3	Q01628	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
种属内	IFITM3	Q01628	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
种属内	IFITM3	Q01628	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
种属内	IFITM3	Q01628	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
种属内	IFITM3	Q01628	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	NAMPT	Homo sapiens	P43490	Y2H	18486613
种属内	IFITM3	Q01628	NAMPT	Homo sapiens	P43490	Anti Bait CoIP	18486613
种属内	IFITM3	Q01628	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
种属内	IFITM3	Q01628	BRI3	Homo sapiens	O95415	Anti Tag CoIP	30983867
种属内	IFITM3	Q01628	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
种属内	IFITM3	Q01628	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
种属内	IFITM3	Q01628	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
种属内	IFITM3	Q01628	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
种属内	IFITM3	Q01628	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
种属内	IFITM3	Q01628	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
种属内	IFITM3	Q01628	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	CD53	Homo sapiens	P19397	Y2H Array	32296183
种属内	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
种属内	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
种属内	IFITM3	Q01628	REEP4	Homo sapiens	Q9H6H4	Anti Tag CoIP	33961781
种属内	IFITM3	Q01628	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	IFITM3	Q01628	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	IFITM3	Q01628	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
种属内	IFITM3	Q01628	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
种属内	IFITM3	Q01628	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
种属内	IFITM3	Q01628	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
种属内	IFITM3	Q01628	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IFITM3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77370	IFITM3/Fragilis Protein, Human (HEK293, Fc)	Q01628/NP_066362.2 (M1-H57)	≥95%

IFITM3 抗体

目录号	产品名	应用	反应物种
HY-P83115	Fragilis Antibody (YA2860)	WB, IHC-F, IHC-P, ICC/IF	Human

关联疾病

疾病名称

别名

Influenza, Severe

Influenza, Severe, Susceptibility To

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Stomatitis

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Rift Valley Fever

Rfv - [Rift Valley Fever]

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Mouth Disease

Mouth Diseases

Mouth Disorders

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06568	IFITM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IFITM3	MGD	MGI:1913391
Rattus norvegicus	IFITM3	RGD	RGD:1595844
Others	IFITM3	NCBI

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