2. Gene
  3. OLFM4 - olfactomedin 4 Gene

OLFM4 - olfactomedin 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：嗅觉调节素 4

种属: Homo sapiens

同用名: GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1

基因 ID: 10562 | 基因类型: protein coding

关于 OLFM4

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:53,028,813-53,052,057 (from NCBI)

This gene has 1 transcript (splice variant), 250 orthologues and 9 paralogues. Biased expression in small intestine (RPKM 721.2), duodenum (RPKM 639.8) and 4 other tissues.

功能概要

该基因最初是从人类成髓细胞中克隆出来的，并被发现在发炎的结肠上皮细胞中有选择性地表达。该基因编码嗅觉调节素家族的一个成员。编码的蛋白是一种促进肿瘤生长的抗凋亡因子，是一种促进细胞粘附的细胞外基质糖蛋白。[RefSeq 提供，2011 年 3 月]

This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

OLFM4 基因产物(1)

mRNA Protein Name
NM_006418.5 NP_006409.3 olfactomedin-4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IMP
IMP: 通过突变表型推断
16566923 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20534456 GOA
enables structural molecule activity IDA
IDA: 通过直接分析推断
16566923 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: 通过直接分析推断
16566923 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
NOT located in azurophil granule IDA
IDA: 通过直接分析推断
23922742 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
23922742 GOA
located in extracellular space IMP
IMP: 通过突变表型推断
16566923 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16566923 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16566923 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
16566923 GOA
NOT located in secretory granule IDA
IDA: 通过直接分析推断
23922742 GOA
located in specific granule IDA
IDA: 通过直接分析推断
23922742 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OLFM4 蛋白结构

OLF

OLF: Olfactomedin-like domain (251 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
蛋白主名 其他名称

olfactomedin-4

G-CSF-stimulated clone 1 protein

重组 OLFM4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71179 OLFM4 Protein, Human (HEK293, His) Q6UX06 (D21-Q510) ≥95%

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Atrophy Of Prostate
Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09773 OLFM4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta OLFM4 VGNC VGNC:75418
Rattus norvegicus OLFM4 RGD RGD:1311708
Canis familiaris OLFM4 VGNC VGNC:49706
Bos taurus OLFM4 VGNC VGNC:32420
Felis catus OLFM4 VGNC VGNC:63961
Mus musculus OLFM4 MGD MGI:2685142
Others OLFM4 NCBI
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