SLU7 - SLU7 homolog, splicing factor Gene

中文名称：SLU7 同系物，剪接因子

种属: Homo sapiens

同用名: 9G8; hSlu7

基因 ID: 10569 | 基因类型: protein coding

关于 SLU7

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,401,641-160,419,081 (from NCBI)

This gene has 9 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues.

功能概要

pre-mRNA 剪接发生在两个连续的酯交换步骤中。由该基因编码的蛋白质是一种剪接因子，已被发现在 pre-mRNA 剪接过程的第二个催化步骤中必不可少。它与剪接体结合并包含在其他剪接因子中发现的锌关节基序，并参与蛋白质-核酸和蛋白质-蛋白质相互作用。[RefSeq 提供，2008 年 7 月]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in Other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

SLU7 基因产物(7)

mRNA	Protein	Name
NM_001364517.2	NP_001351446.1	pre-mRNA-splicing factor SLU7 isoform a
NM_001364518.2	NP_001351447.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364520.2	NP_001351449.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364521.2	NP_001351450.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364522.2	NP_001351451.1	pre-mRNA-splicing factor SLU7 isoform c
NM_001364523.2	NP_001351452.1	pre-mRNA-splicing factor SLU7 isoform c
NM_006425.5	NP_006416.3	pre-mRNA-splicing factor SLU7 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables pre-mRNA 3'-splice site binding	IDA IDA: 通过直接分析推断	15728250	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables second spliceosomal transesterification activity	IDA IDA: 通过直接分析推断	10197984	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	15181151	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RNA splicing, via transesterification reactions	IDA IDA: 通过直接分析推断	10197984	GOA
involved in alternative mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	15728250	GOA
involved in cellular response to heat	IDA IDA: 通过直接分析推断	21122810	GOA
involved in intracellular protein transport	IDA IDA: 通过直接分析推断	21122810	GOA
involved in mRNA 3'-splice site recognition	IDA IDA: 通过直接分析推断	15728250	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	21122810	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	15728250	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21122810	GOA
part of small nuclear ribonucleoprotein complex	IDA IDA: 通过直接分析推断	15181151	GOA
part of spliceosomal complex	IDA IDA: 通过直接分析推断	10197984	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLU7 蛋白结构

Slu7

0
100
200
300
400
500
586 a.a.

蛋白主名

其他名称

pre-mRNA-splicing factor SLU7

SLU7 splicing factor homolog

SLU7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLU7	O95391	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
种属内	SLU7	O95391	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
种属内	SLU7	O95391	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
种属内	SLU7	O95391	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
种属内	SLU7	O95391	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
种属内	SLU7	O95391	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
种属内	SLU7	O95391	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
种属内	SLU7	O95391	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
种属内	SLU7	O95391	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
种属内	SLU7	O95391	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
种属内	SLU7	O95391	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
种属内	SLU7	O95391	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
种属内	SLU7	O95391	MCC	Homo sapiens	P23508	Validated Y2H	32296183
种属内	SLU7	O95391	MCC	Homo sapiens	P23508	Y2H Array	32296183
种属内	SLU7	O95391	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	NSD3	Homo sapiens	Q9BZ95	Anti Tag CoIP	23455924
种属内	SLU7	O95391	NSD3	Homo sapiens	Q9BZ95	Y2H	23455924
种属内	SLU7	O95391	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	22365833
种属内	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
种属内	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
种属内	SLU7	O95391	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
种属内	SLU7	O95391	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
种属内	SLU7	O95391	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
种属内	SLU7	O95391	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
种属内	SLU7	O95391	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
种属内	SLU7	O95391	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
种属内	SLU7	O95391	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
种属内	SLU7	O95391	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
种属内	SLU7	O95391	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
种属内	SLU7	O95391	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
种属内	SLU7	O95391	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
种属内	SLU7	O95391	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
种属内	SLU7	O95391	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
种属内	SLU7	O95391	GFAP	Homo sapiens	P14136	Y2H Array	32814053
种属内	SLU7	O95391	AIMP2	Homo sapiens	Q13155	Y2H Array	32296183
种属内	SLU7	O95391	AIMP2	Homo sapiens	Q13155	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	AIMP2	Homo sapiens	Q13155	Validated Y2H	32296183
种属内	SLU7	O95391	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	32296183
种属内	SLU7	O95391	SF3B2	Homo sapiens	Q13435	Y2H	22365833
种属内	SLU7	O95391	PPIL3	Homo sapiens	Q9H2H8	Y2H Prey Pooling	25416956
种属内	SLU7	O95391	PPIL3	Homo sapiens	Q9H2H8	Y2H Array	25416956
种属内	SLU7	O95391	PPIL3	Homo sapiens	Q9H2H8	Y2H Pooling	16189514
种属内	SLU7	O95391	IKBKG	Homo sapiens	Q9Y6K9	Y2H Array	32296183
种属内	SLU7	O95391	IKBKG	Homo sapiens	Q9Y6K9	Y2H Prey Pooling	32296183
种属内	SLU7	O95391	IKBKG	Homo sapiens	Q9Y6K9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13384	SLU7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLU7	MGD	MGI:2385598
Canis familiaris	SLU7	VGNC	VGNC:46515
Bos taurus	SLU7	VGNC	VGNC:34971
Macaca mulatta	SLU7	VGNC	VGNC:77728
Felis catus	SLU7	VGNC	VGNC:65457
Rattus norvegicus	SLU7	RGD	RGD:631432

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