2. Gene
  3. SLU7 - SLU7 homolog, splicing factor Gene

SLU7 - SLU7 homolog, splicing factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SLU7 同系物，剪接因子

种属: Homo sapiens

同用名: 9G8; hSlu7

基因 ID: 10569 | 基因类型: protein coding

关于 SLU7

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,401,641-160,419,081 (from NCBI)

This gene has 9 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues.

功能概要

pre-mRNA 剪接发生在两个连续的酯交换步骤中。由该基因编码的蛋白质是一种剪接因子，已被发现在 pre-mRNA 剪接过程的第二个催化步骤中必不可少。它与剪接体结合并包含在其他剪接因子中发现的锌关节基序，并参与蛋白质-核酸和蛋白质-蛋白质相互作用。[RefSeq 提供，2008 年 7 月]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

SLU7 基因产物(7)

mRNA Protein Name
NM_001364517.2 NP_001351446.1 pre-mRNA-splicing factor SLU7 isoform a
NM_001364518.2 NP_001351447.1 pre-mRNA-splicing factor SLU7 isoform b
NM_001364520.2 NP_001351449.1 pre-mRNA-splicing factor SLU7 isoform b
NM_001364521.2 NP_001351450.1 pre-mRNA-splicing factor SLU7 isoform b
NM_001364522.2 NP_001351451.1 pre-mRNA-splicing factor SLU7 isoform c
NM_001364523.2 NP_001351452.1 pre-mRNA-splicing factor SLU7 isoform c
NM_006425.5 NP_006416.3 pre-mRNA-splicing factor SLU7 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables pre-mRNA 3'-splice site binding IDA
IDA: 通过直接分析推断
15728250 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables second spliceosomal transesterification activity IDA
IDA: 通过直接分析推断
10197984 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
15181151 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA splicing, via transesterification reactions IDA
IDA: 通过直接分析推断
10197984 GOA
involved in alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
15728250 GOA
involved in cellular response to heat IDA
IDA: 通过直接分析推断
21122810 GOA
involved in intracellular protein transport IDA
IDA: 通过直接分析推断
21122810 GOA
involved in mRNA 3'-splice site recognition IDA
IDA: 通过直接分析推断
15728250 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21122810 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
15728250 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21122810 GOA
part of small nuclear ribonucleoprotein complex IDA
IDA: 通过直接分析推断
15181151 GOA
part of spliceosomal complex IDA
IDA: 通过直接分析推断
10197984 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLU7 蛋白结构

Slu7

Slu7: Pre-mRNA splicing Prp18-interacting factor (161 - 434)

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  • 500
  • 586 a.a.
蛋白主名 其他名称

pre-mRNA-splicing factor SLU7

SLU7 splicing factor homolog

SLU7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLU7 O95391 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra SLU7 O95391 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra SLU7 O95391 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra SLU7 O95391 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra SLU7 O95391 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra SLU7 O95391 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra SLU7 O95391 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra SLU7 O95391 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra SLU7 O95391 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra SLU7 O95391 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra SLU7 O95391 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra SLU7 O95391 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra SLU7 O95391 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra SLU7 O95391 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra SLU7 O95391 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra SLU7 O95391 MCC Homo sapiens P23508
Validated Y2H
32296183
Intra SLU7 O95391 MCC Homo sapiens P23508
Y2H Array
32296183
Intra SLU7 O95391 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra SLU7 O95391 NSD3 Homo sapiens Q9BZ95
Anti Tag CoIP
23455924
Intra SLU7 O95391 NSD3 Homo sapiens Q9BZ95
Y2H
23455924
Intra SLU7 O95391 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
22365833
Intra SLU7 O95391 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra SLU7 O95391 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra SLU7 O95391 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra SLU7 O95391 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra SLU7 O95391 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra SLU7 O95391 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra SLU7 O95391 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra SLU7 O95391 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra SLU7 O95391 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra SLU7 O95391 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra SLU7 O95391 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra SLU7 O95391 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra SLU7 O95391 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra SLU7 O95391 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra SLU7 O95391 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra SLU7 O95391 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra SLU7 O95391 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra SLU7 O95391 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra SLU7 O95391 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra SLU7 O95391 AIMP2 Homo sapiens Q13155
Y2H Array
32296183
Intra SLU7 O95391 AIMP2 Homo sapiens Q13155
Y2H Prey Pooling
32296183
Intra SLU7 O95391 AIMP2 Homo sapiens Q13155
Validated Y2H
32296183
Intra SLU7 O95391 DEF6 Homo sapiens Q9H4E7
Validated Y2H
32296183
Intra SLU7 O95391 SF3B2 Homo sapiens Q13435
Y2H
22365833
Intra SLU7 O95391 PPIL3 Homo sapiens Q9H2H8
Y2H Prey Pooling
25416956
Intra SLU7 O95391 PPIL3 Homo sapiens Q9H2H8
Y2H Array
25416956
Intra SLU7 O95391 PPIL3 Homo sapiens Q9H2H8
Y2H Pooling
16189514
Intra SLU7 O95391 IKBKG Homo sapiens Q9Y6K9
Y2H Array
32296183
Intra SLU7 O95391 IKBKG Homo sapiens Q9Y6K9
Y2H Prey Pooling
32296183
Intra SLU7 O95391 IKBKG Homo sapiens Q9Y6K9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage

Alcoholic Gastritis, Without Mention Of Hemorrhage

Alcohol Gastritis

Etoh Gastritis
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13384 SLU7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLU7 MGD MGI:2385598
Canis familiaris SLU7 VGNC VGNC:46515
Bos taurus SLU7 VGNC VGNC:34971
Macaca mulatta SLU7 VGNC VGNC:77728
Felis catus SLU7 VGNC VGNC:65457
Rattus norvegicus SLU7 RGD RGD:631432
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