TXNIP - thioredoxin interacting protein Gene

中文名称：硫氧还蛋白相互作用蛋白

种属: Homo sapiens

同用名: THIF; VDUP1; ARRDC6; HHCPA78; EST01027

基因 ID: 10628 | 基因类型: protein coding

关于 TXNIP

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,992,435-145,996,579 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 1044.5), spleen (RPKM 514.7) and 23 other tissues.

功能概要

该基因编码的硫氧还蛋白结合蛋白是α抑制蛋白家族的一员。硫氧还蛋白是一种硫醇氧化还原酶，是细胞氧化还原信号的主要调节因子，可保护细胞免受氧化应激。这种蛋白质抑制硫氧还蛋白的抗氧化功能，导致活性氧物质的积累和细胞应激。这种蛋白质还可以作为细胞代谢和内质网 (ER) 应激的调节剂。这种蛋白质也可以作为肿瘤抑制因子发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供，2015 年 9 月]

This gene encodes a thioredoxin-binding protein that is a member of the alpha Arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of Reactive Oxygen Species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

TXNIP 基因产物(2)

mRNA	Protein	Name
NM_001313972.2	NP_001300901.1	thioredoxin-interacting protein isoform 2
NM_006472.6	NP_006463.3	thioredoxin-interacting protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme inhibitor activity	IDA IDA: 通过直接分析推断	17603038	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10814541	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	20068034	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to tumor cell	IDA IDA: 通过直接分析推断	18541147	GOA
involved in keratinocyte differentiation	IDA IDA: 通过直接分析推断	14632196	GOA
involved in negative regulation of cell division	IDA IDA: 通过直接分析推断	18541147	GOA
involved in response to oxidative stress	IDA IDA: 通过直接分析推断	17603038	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	14632196	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TXNIP 蛋白结构

Arrestin_N

Arrestin_C

0
100
200
300
391 a.a.

蛋白主名

其他名称

thioredoxin-interacting protein

thioredoxin binding protein 2

TXNIP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TXNIP	Q9H3M7	ECD	Homo sapiens	O95905	Anti Tag CoIP	38270169
种属内	TXNIP	Q9H3M7	VAV2	Homo sapiens	P52735	ITC	26919541
种属内	TXNIP	Q9H3M7	VAV2	Homo sapiens	P52735	X-Ray Diffraction	26919541
种属内	TXNIP	Q9H3M7	HDAC2	Homo sapiens	Q92769	Anti Bait CoIP	38270169
种属内	TXNIP	Q9H3M7	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	38270169
种属内	TXNIP	Q9H3M7	TXN	Homo sapiens	P10599	Y2H	10814541
种属内	TXNIP	Q9H3M7	TXN	Homo sapiens	P10599	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

TXNIP 抗体

目录号	产品名	应用	反应物种
HY-P81882	Thioredoxin Interacting Protein Antibody (YA1627)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Leukostasis

Hyperglycemia

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia	Combined Hyperlipidemia, Familial
Mixed Hyperlipidaemia	FCHL3
Hyperlipidemia, Familial Combined	Familial Multiple Lipoprotein-Type Hyperlipidemia
Hyperbetalipoproteinemia With Prebetalipoproteinemia	Type Iib Hyperlipoproteinemia
Hyperlipidemia Familial Combined	Hyperlipoproteinemia Type Iib
Mixed Hyperlipemia	Hyperlipidaemia, Group C
Familial Hypercholesterolaemia With Hyperlipaemia	Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia
Hyperbetalipoproteinaemia With Prebetalipoproteinaemia	Hypercholesterolaemia With Endogenous Hyperglyceridaemia
Prebetalipoproteinemia Hyperbetalipoproteinaemia	Remnant Hyperlipoproteinemia

Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0004	Doxofylline		99.65%	是

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19330	DASA-58	Activator	99.73%	否
HY-142114	SRI-37330	Inhibitor	98.76%	否
HY-141623	SRI-37330 hydrochloride	Inhibitor	99.72%	否
HY-115688	TXNIP-IN-1	Inhibitor	99.15%	否
HY-N0496	Ruscogenin	Inhibitor	99.59%	否
HY-122682	SBI-993		98.67%	否
HY-124418	SBI-477		≥98.0%	否
HY-RS15295	TXNIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-115688A	(S)-TXNIP-IN-1		99.73%	否
HY-149216	Anticancer agent 103		/	否
HY-155248	HL23		/	否
HY-169298	Ferroptosis-IN-15	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TXNIP	VGNC	VGNC:79059
Canis familiaris	TXNIP	VGNC	VGNC:48017
Felis catus	TXNIP	VGNC	VGNC:66730
Bos taurus	TXNIP	VGNC	VGNC:36541
Rattus norvegicus	TXNIP	RGD	RGD:620886
Mus musculus	TXNIP	MGD	MGI:1889549
Others	TXNIP	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TXNIP - thioredoxin interacting protein Gene

关于 TXNIP

功能概要

TXNIP 基因产物(2)

TXNIP 蛋白结构

TXNIP 蛋白互作信息

TXNIP 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TXNIP - thioredoxin interacting protein Gene

关于 TXNIP

功能概要

TXNIP 基因产物(2)

TXNIP 蛋白结构

TXNIP 蛋白互作信息

TXNIP 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z