2. Gene
  3. PGRMC1 - progesterone receptor membrane component 1 Gene

PGRMC1 - progesterone receptor membrane component 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：孕酮受体膜成分 1

种属: Homo sapiens

同用名: IZA; MPR; Dap1; HPR6.6

基因 ID: 10857 | 基因类型: protein coding

关于 PGRMC1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,236,285-119,244,466 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues.

功能概要

该基因编码一种假定的膜相关黄体酮类固醇受体。该蛋白质主要在肝脏和肾脏中表达。[RefSeq 提供，2010 年 3 月]

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

PGRMC1 基因产物(2)

mRNA Protein Name
NM_001282621.2 NP_001269550.1 membrane-associated progesterone receptor component 1 isoform 2
NM_006667.5 NP_006658.1 membrane-associated progesterone receptor component 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heme binding IDA
IDA: 通过直接分析推断
26988023 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21081644 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
26988023 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heme biosynthetic process IDA
IDA: 通过直接分析推断
27599036 GOA
involved in positive regulation of lipoprotein transport IMP
IMP: 通过突变表型推断
30443021 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
25390692 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PGRMC1 蛋白结构

Cyt-b5

Cyt-b5: Cytochrome b5-like Heme/Steroid binding domain (73 - 170)

  • 0
  • 100
  • 195 a.a.
蛋白主名 其他名称

membrane-associated progesterone receptor component 1

progesterone binding protein

PGRMC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Anti Tag CoIP
35271311
种属内
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Validated Y2H
32296183
种属内
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
种属内
PGRMC1 O00264 KCNE5 Homo sapiens Q9UJ90
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 KCNE5 Homo sapiens Q9UJ90
Validated Y2H
32296183
种属内
PGRMC1 O00264 KCNE5 Homo sapiens Q9UJ90
Y2H Array
32296183
种属内
PGRMC1 O00264 DEFB124 Homo sapiens Q8NES8
Validated Y2H
32296183
种属内
PGRMC1 O00264 DEFB124 Homo sapiens Q8NES8
Y2H Array
32296183
种属内
PGRMC1 O00264 DEFB124 Homo sapiens Q8NES8
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 CAMLG Homo sapiens P49069
Validated Y2H
32296183
种属内
PGRMC1 O00264 CAMLG Homo sapiens P49069
Y2H Array
32296183
种属内
PGRMC1 O00264 EVI2B Homo sapiens P34910-2
Validated Y2H
32296183
种属内
PGRMC1 O00264 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
种属内
PGRMC1 O00264 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 GET3 Homo sapiens O43681
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 GET3 Homo sapiens O43681
Validated Y2H
32296183
种属内
PGRMC1 O00264 GET3 Homo sapiens O43681
Y2H Array
32296183
种属内
PGRMC1 O00264 DHCR24 Homo sapiens Q15392
Anti Tag CoIP
35271311
种属内
PGRMC1 O00264 BIK Homo sapiens Q13323
Validated Y2H
32296183
种属内
PGRMC1 O00264 BIK Homo sapiens Q13323
Y2H Array
32296183
种属内
PGRMC1 O00264 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
种属内
PGRMC1 O00264 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
种属内
PGRMC1 O00264 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 ZNF71 Homo sapiens Q9NQZ8
Y2H Array
32296183
种属内
PGRMC1 O00264 ZNF71 Homo sapiens Q9NQZ8
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 ZNF71 Homo sapiens Q9NQZ8
Validated Y2H
32296183
种属内
PGRMC1 O00264 CIAO1 Homo sapiens O76071
Validated Y2H
32296183
种属内
PGRMC1 O00264 CIAO1 Homo sapiens O76071
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 CIAO1 Homo sapiens O76071
Y2H Array
32296183
种属内
PGRMC1 O00264 POR Homo sapiens P16435
Anti Tag CoIP
21081644
种属内
PGRMC1 O00264 POR Homo sapiens P16435
Anti Tag CoIP
35271311
种属内
PGRMC1 O00264 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
PGRMC1 O00264 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
PGRMC1 O00264 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
种属内
PGRMC1 O00264 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
种属内
PGRMC1 O00264 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
种属内
PGRMC1 O00264 CCDC134 Homo sapiens Q9H6E4
Validated Y2H
32296183
种属内
PGRMC1 O00264 CCDC134 Homo sapiens Q9H6E4
Y2H Array
32296183
种属内
PGRMC1 O00264 CCDC134 Homo sapiens Q9H6E4
Y2H Prey Pooling
32296183
种属间
PGRMC1 O00264 CYP2C2 Oryctolagus cuniculus P00181
Confocal
21081644
种属间
PGRMC1 O00264 CYP2C2 Oryctolagus cuniculus P00181
Anti Tag CoIP
21081644
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor

Extragonadal Germ Cell Malignant Tumor

Neoplasm Of Extragonadal Germ Cell

Tumor Of Extragonadal Germ Cell
Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes

PPROM

Preterm Premature Rupture Of The Membranes, Susceptibility To

Pprom - [Preterm Premature Rupture Of Membranes]

Preterm Rupture Of Membranes
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C

NPC1

Niemann-Pick Disease, Type D

Niemann-Pick Disease Type C1

Niemann-Pick Disease With Cholesterol Esterification Block

Niemann-Pick Disease, Subacute Juvenile Form

Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

Npc

Niemann-Pick Disease, Chronic Neuronopathic Form

Niemann-Pick Disease Without Sphingomyelinase Deficiency

Niemann-Pick Disease Type C

Niemann-Pick Disease Type D

Niemann-Pick C1 Disease

Niemann-Pick Disease C1

Niemann-Pick Disease Chronic Neuronopathic Form

Niemann-Pick Disease Nova Scotian Type

Niemann-Pick Disease Subacute Juvenile Form

Niemann-Pick Disease Type Ii

Niemann-Picks Disease Type C
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115625 AG-205 / 否
HY-121012 (rac)-AG-205 / 否
HY-RS10399 PGRMC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PGRMC1 VGNC VGNC:75806
Canis familiaris PGRMC1 VGNC VGNC:44470
Mus musculus PGRMC1 MGD MGI:1858305
Rattus norvegicus PGRMC1 RGD RGD:70890
Bos taurus PGRMC1 VGNC VGNC:32801
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