CPSF4 - cleavage and polyadenylation specific factor 4 Gene

中文名称：裂解和聚腺苷酸化特异性因子 4

种属: Homo sapiens

同用名: NAR; NEB1; NEB-1; CPSF30

关于 CPSF4

功能概要

抑制由甲型流感病毒 NS1 蛋白引起的含有 poly (A) 的 mRNA 的核输出需要其效应域。 NS1 效应域在功能上与裂解的细胞 30 kDa 亚基和聚腺苷酸化特异性因子 4 相互作用，后者是细胞前体 mRNA 3' 末端加工机制的重要组成部分。在流感病毒感染的细胞中，NS1 蛋白与切割和聚腺苷酸化特异性因子 4、30kD 亚基物理相关。 NS1 蛋白在体外与 30 kDa 蛋白的结合可防止 CPSF 与 RNA 底物结合，并抑制宿主前体 mRNA 的 3' 端切割和聚腺苷酸化。因此，NS1 蛋白选择性地抑制细胞而非病毒 mRNA 的核输出。已针对该基因描述了编码不同亚型的多个选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]