1. Gene
  2. SUB1 - SUB1 regulator of transcription Gene

SUB1 - SUB1 regulator of transcription Gene

中文名称:SUB1 转录调节因子

种属: Homo sapiens

同用名: P15; PC4; p14

基因 ID: 10923 | 基因类型: protein coding

关于 SUB1

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,585,557-32,604,079 (from NCBI)

This gene has 13 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in brain (RPKM 41.5), fat (RPKM 34.4) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性;单链 DNA 结合活性;和转录共激活因子活性。参与 DNA 代谢过程的负调控和 RNA 聚合酶 II 的转录调控。位于核仁和核质中。转录调节复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SUB1 基因产物(1)

mRNA Protein Name
NM_006713.4 NP_006704.3 activated RNA polymerase II transcriptional coactivator p15
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16415882 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9847329 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
8062391 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
8062391 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA polymerase II promoter clearance IDA
IDA: 通过直接分析推断
25308091 GOA
involved in negative regulation of DNA duplex unwinding IDA
IDA: 通过直接分析推断
16605275 GOA
involved in negative regulation of DNA metabolic process IDA
IDA: 通过直接分析推断
28369605 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8062391 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription regulator complex IDA
IDA: 通过直接分析推断
8062391 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SUB1 蛋白结构

PC4

PC4: Transcriptional Coactivator p15 (PC4) (63 - 116)

  • 0
  • 100
  • 127 a.a.
蛋白主名 其他名称

activated RNA polymerase II transcriptional coactivator p15

SUB1 homolog, transcriptional regulator

SUB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SUB1 P53999 CSTF2 Homo sapiens P33240-1
Anti Bait CoIP
11389848
种属内
SUB1 P53999 SUB1 Homo sapiens P53999
X-Ray Diffraction
16415882
种属内
SUB1 P53999 SUB1 Homo sapiens P53999
Validated Y2H
32296183
种属内
SUB1 P53999 SUB1 Homo sapiens P53999
Y2H Array
25416956
种属内
SUB1 P53999 SUB1 Homo sapiens P53999
Y2H Array
32296183
种属内
SUB1 P53999 SUB1 Homo sapiens P53999
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SUB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74650 PC4/SUB1 Protein, Human (His) P53999 (M1-L127) ≥95%

关联疾病

疾病名称 别名
Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4

DKCB5

Autosomal Dominant Dyskeratosis Congenita 4

DKCA4

Autosomal Recessive Dyskeratosis Congenita 5

Dyskeratosis Congenita, Autosomal Recessive, 5

Dyskeratosis Congenita, Autosomal Dominant 4

Dyskeratosis Congenita, Autosomal Recessive, Type 5

Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SUB1 MGD MGI:104811
Rattus norvegicus SUB1 RGD RGD:621582
Bos taurus SUB1 VGNC VGNC:35454
Macaca mulatta SUB1 VGNC VGNC:110431
Others SUB1 NCBI