1. Gene
  2. YWHAQ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Gene

YWHAQ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Gene

中文名称:酪氨酸 3-单加氧酶/色氨酸 5-单加氧酶活化蛋白 theta

种属: Homo sapiens

同用名: 1C5; HS1; 14-3-3

基因 ID: 10971 | 基因类型: protein coding

关于 YWHAQ

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,583,967-9,630,997 (from NCBI)

This gene has 5 transcripts (splice variants), 275 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 160.3), endometrium (RPKM 117.5) and 25 other tissues.

功能概要

该基因产物属于 14-3-3 蛋白家族,通过与含磷酸丝氨酸的蛋白结合来介导信号转导。这种高度保守的蛋白质家族存在于植物和哺乳动物中,并且这种蛋白质与小鼠和大鼠的直系同源物具有 99% 的相同性。该基因在肌萎缩侧索硬化症患者中上调。它在其 5' UTR 中包含一个 6 bp 的串联重复序列,该序列是多态性的,但重复数与疾病之间没有相关性。[RefSeq 提供,2008 年 7 月]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

YWHAQ 基因产物(1)

mRNA Protein Name
NM_006826.4 NP_006817.1 2014/3/3 protein theta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17085597 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7760835 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15163635 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15163635 GOA
located in nucleus IDA
IDA: 通过直接分析推断
31906564 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
22797923 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

YWHAQ 蛋白结构

14-3-3

14-3-3: 14-3-3 protein (4 - 235)

  • 0
  • 100
  • 200
  • 245 a.a.
蛋白主名 其他名称

14-3-3 protein theta

14-3-3 protein T-cell

YWHAQ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
YWHAQ P27348 MPRIP Homo sapiens Q6WCQ1 35271311
种属内
YWHAQ P27348 MPRIP Homo sapiens Q6WCQ1 17353931
种属内
YWHAQ P27348 MPRIP Homo sapiens Q6WCQ1 33961781
种属内
YWHAQ P27348 MPRIP Homo sapiens Q6WCQ1 28514442
种属内
YWHAQ P27348 MPRIP Homo sapiens Q6WCQ1 36931259
种属内
YWHAQ P27348 CDK14 Homo sapiens O94921
Y2H
16775625
种属内
YWHAQ P27348 CDK14 Homo sapiens O94921 16775625
种属内
YWHAQ P27348 CDK14 Homo sapiens O94921 36931259
种属内
YWHAQ P27348 PI4KB Homo sapiens Q9UBF8 36931259
种属内
YWHAQ P27348 PI4KB Homo sapiens Q9UBF8 33961781
种属内
YWHAQ P27348 PI4KB Homo sapiens Q9UBF8 28514442
种属内
YWHAQ P27348 PI4KB Homo sapiens Q9UBF8 35271311
种属内
YWHAQ P27348 PI4KB Homo sapiens Q9UBF8 17353931
种属内
YWHAQ P27348 CCDC125 Homo sapiens Q86Z20 32296183
种属内
YWHAQ P27348 ADAM22 Homo sapiens Q9P0K1-3
Y2H
16868027
种属内
YWHAQ P27348 KIF1C Homo sapiens O43896 36931259
种属内
YWHAQ P27348 KIF1C Homo sapiens O43896 33961781
种属内
YWHAQ P27348 KIF1C Homo sapiens O43896 28514442
种属内
YWHAQ P27348 KANK1 Homo sapiens Q14678 19559006
种属内
YWHAQ P27348 KANK1 Homo sapiens Q14678 18458160
种属内
YWHAQ P27348 EGFR Homo sapiens P00533 24658140
种属内
YWHAQ P27348 MAP3K3 Homo sapiens Q99759 33961781
种属内
YWHAQ P27348 MAP3K3 Homo sapiens Q99759 28514442
种属内
YWHAQ P27348 MAP3K3 Homo sapiens Q99759 36931259
种属内
YWHAQ P27348 HDAC4 Homo sapiens P56524 33961781
种属内
YWHAQ P27348 HDAC4 Homo sapiens P56524 28514442
种属内
YWHAQ P27348 HDAC4 Homo sapiens P56524 36931259
种属内
YWHAQ P27348 FGA Homo sapiens P02671 28514442
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258 20936779
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258 33961781
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258 36931259
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258 21988832
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258 28514442
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258
Y2H
21988832
种属内
YWHAQ P27348 YWHAE Homo sapiens P62258 35271311
种属内
YWHAQ P27348 YWHAB Homo sapiens P31946 28514442
种属内
YWHAQ P27348 YWHAB Homo sapiens P31946 35271311
种属内
YWHAQ P27348 YWHAB Homo sapiens P31946 36931259
种属内
YWHAQ P27348 YWHAG Homo sapiens P61981 35271311
种属内
YWHAQ P27348 YWHAG Homo sapiens P61981 17085597
种属内
YWHAQ P27348 YWHAG Homo sapiens P61981 28514442
种属内
YWHAQ P27348 YWHAG Homo sapiens P61981 36931259
种属内
YWHAQ P27348 RAF1 Homo sapiens P04049 36931259
种属内
YWHAQ P27348 RAF1 Homo sapiens P04049 33961781
种属内
YWHAQ P27348 RAF1 Homo sapiens P04049 28514442
种属内
YWHAQ P27348 RAF1 Homo sapiens P04049 35271311
种属内
YWHAQ P27348 RAF1 Homo sapiens P04049 17353931
种属内
YWHAQ P27348 CBL Homo sapiens P22681 11697890
种属内
YWHAQ P27348 CBL Homo sapiens P22681 36931259
种属内
YWHAQ P27348 CBL Homo sapiens P22681 8663231
种属内
YWHAQ P27348 CBL Homo sapiens P22681 11697890
种属内
YWHAQ P27348 TRIM42 Homo sapiens Q8IWZ5 25416956
种属内
YWHAQ P27348 LRRK2 Homo sapiens Q5S007
FPS
24351927
种属内
YWHAQ P27348 KANK1 Homo sapiens Q14678-2 18458160
种属内
YWHAQ P27348 BAD Homo sapiens Q92934
Y2H
21988832
种属内
YWHAQ P27348 BAD Homo sapiens Q92934 28514442
种属内
YWHAQ P27348 BAD Homo sapiens Q92934 36931259
种属内
YWHAQ P27348 BAD Homo sapiens Q92934 33961781
种属内
YWHAQ P27348 ITPRID2 Homo sapiens P28290 33961781
种属内
YWHAQ P27348 ITPRID2 Homo sapiens P28290 28514442
种属内
YWHAQ P27348 ITPRID2 Homo sapiens P28290 36931259
种属内
YWHAQ P27348 CDC25A Homo sapiens P30304 19289404
种属内
YWHAQ P27348 FSHR Homo sapiens P23945
Y2H
15196694
种属内
YWHAQ P27348 FSHR Homo sapiens P23945 20600589
种属内
YWHAQ P27348 FSHR Homo sapiens P23945 15196694
种属内
YWHAQ P27348 ATXN1 Homo sapiens P54253 32814053
种属内
YWHAQ P27348 ATXN1 Homo sapiens P54253 36931259
种属内
YWHAQ P27348 ATXN1 Homo sapiens P54253 32814053
种属内
YWHAQ P27348 ATXN1 Homo sapiens P54253 32814053
种属间
YWHAQ P27348 tir Escherichia coli O127:H6 B7UM99
IF
16367866
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 YWHAQ 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75548 14-3-3 theta Protein, Human (GST) P27348 (M1-N245) ≥95%

YWHAQ 抗体

目录号 产品名 应用 反应物种
HY-P82210 14-3-3 theta Antibody (YA1955) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Lateral Sclerosis

Primary Lateral Sclerosis

Adult-Onset Primary Lateral Sclerosis

Adult-Onset Pls

Motor Neuron Disease

Pls

Pls - [Primary Lateral Sclerosis]

Lateral Spinal Sclerosis

Lateral Complete Paralysis

Lateral Incomplete Paralysis

Lateral Paralysis

Alzheimer Disease 11

Ad11

Alzheimer'S Disease 11

Alzheimer Disease, Familial, 11

Alzheimer Disease-11

Alzheimer'S Disease 11, Late Onset

Anterior Cerebral Artery Infarction

Infarction, Anterior Cerebral Artery

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary

Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1

Guam Disease

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam

Als-Pdc

Lytico-Bodig Disease

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome

Parkinsonism-Dementia-Als Complex

Pdals

Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam

Parkinson-Dementia Complex Of Guam

G-Pdc

Guam Parkinsonism-Dementia Complex

ALS-PDC1

Als/Pdc Of Guam

Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1

Amyotrophic Lateral Sclerosis, Guam Form

Parkinsonian Disorders

Mild Cognitive Impairment
Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]

Movement Disease

Movement Disorders

Movement Disorder

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus YWHAQ VGNC VGNC:81261
Bos taurus YWHAQ VGNC VGNC:37047
Rattus norvegicus YWHAQ RGD RGD:3979
Mus musculus YWHAQ MGD MGI:891963
Others YWHAQ NCBI