Abl1 - c-abl oncogene 1, non-receptor tyrosine kinase Gene

中文名称：c-abl 致癌基因 1 ， 非受体酪氨酸激酶

种属: Mus musculus

同用名: Abl; c-Abl; E430008G22Rik

关于 Abl1

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；金属离子结合活性；和信号受体结合活性。涉及多个过程，包括长期突触增强的负调节；血管分支的正调节；和参与发芽血管生成的细胞迁移的正调节。作用于多个过程的上游或内部，包括细胞表面受体信号通路；造血或淋巴器官发育；和信号转导的调节。位于几种细胞成分中，包括肌动蛋白细胞骨架；细胞前沿；和核。以多种结构表达，包括消化系统；脑;泌尿生殖系统；心;和感觉器官。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；白血病（多发性）；和肺非小细胞癌。与人类 ABL1（ABL 原癌基因 1，非受体酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of blood vessel branching; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]