Ace - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Gene

中文名称：血管紧张素 I 转化酶 (肽基二肽酶 A) 1

种属: Mus musculus

同用名: CD143

关于 Ace

功能概要

该基因编码的蛋白可启动金属肽酶活性和肽基二肽酶活性。参与多个过程，包括骨髓细胞增殖；蛋白质修饰过程的正调控；和基因表达的调控。作用于多个过程的上游或内部，包括心脏收缩；中性粒细胞介导的免疫；和全身动脉血压的正调节。位于细胞质和质膜中。以多种结构表达，包括消化系统；脑;胚外成分；泌尿生殖系统；和外皮系统。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；自身免疫性疾病（多种）；胃肠系统癌症（多发性）；心脏瓣膜病（多发）；和肺部疾病（多种）。与人类 ACE（血管紧张素 I 转化酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting Enzyme). [provided by Alliance of Genome Resources, Apr 2022]