ACE - angiotensin I converting enzyme Gene

中文名称：血管紧张素 I 转化酶

种属: Rattus norvegicus

同用名: Dcp1; CD143; StsRR92

关于 ACE

功能概要

实现杂环化合物结合活性；金属肽酶活性；和肽基二肽酶活性。参与多个过程，包括动物器官发育；运输的负面监管；和对皮质类固醇的反应。位于多种细胞成分中，包括基底质膜；刷状缘膜；和精子中段。用于研究多种疾病，包括动脉疾病（多种）；肾小球肾炎（多发性）；肾功能衰竭（多发）；肺部疾病（多发）；和蛋白尿（多次）。多种疾病的生物标志物，包括动脉疾病（多种）；先天性膈疝;心内膜心肌纤维化；肝硬化（多发性）；和肺部疾病（多种）。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；自身免疫性疾病（多种）；胃肠系统癌症（多发性）；心脏瓣膜病（多发）；和肺部疾病（多种）。与人类 ACE（血管紧张素 I 转化酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting Enzyme). [provided by Alliance of Genome Resources, Apr 2022]