Braf - B-Raf proto-oncogene, serine/threonine kinase Gene

中文名称：B-Raf 原癌基因， 丝氨酸/苏氨酸激酶

种属: Rattus norvegicus

关于 Braf

功能概要

该基因编码的蛋白可启动 MAP 激酶激酶激酶活性；丝裂原活化蛋白激酶激酶结合活性；和小的 GTPase 结合活性。参与多个过程，包括细胞对神经生长因子刺激的反应； ERK1 和 ERK2 级联的正调控；和对 cAMP 的反应。位于神经元投射；核;和质膜。用于研究胆管腺瘤；胆管癌；肝内胆管癌；和甲状腺乳头状癌。该基因的人类直系同源基因与多种疾病有关，包括努南综合征 7；癌（多发性）；心面皮肤综合征（多发性）；中枢神经系统良性肿瘤（多发性）；和黑色素瘤（多发）。人类 BRAF（B-Raf 原癌基因，丝氨酸/苏氨酸激酶）的直系同源物。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Located in neuron projection; nucleus; and plasma membrane. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRaf (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]