2. Gene
  3. Bak1 - BCL2-antagonist/killer 1 Gene

Bak1 - BCL2-antagonist/killer 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：BCL2-拮抗因子/杀手 1

种属: Rattus norvegicus

同用名: Bak

基因 ID: 116502 | 基因类型: protein coding

关于 Bak1

Primary_assembly 20: 5,100,480-5,109,264 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 135 orthologues, 13 paralogues and is associated with 15 phenotypes. Biased expression in Thymus (RPKM 137.4), Spleen (RPKM 16.9) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括伴侣绑定活动；热休克蛋白结合活性；和相同的蛋白质结合活性。参与多个过程，包括动物器官发育；正调节细胞色素 c 从线粒体中释放；和从线粒体中释放细胞色素 c。位于胞质溶胶中；膜;和线粒体。间歇性跛行的生物标志物。该基因的人类直系同源物与共济失调毛细血管扩张症和宫颈癌有关。与人类 BAK1（BCL2 拮抗剂/杀手 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including chaperone binding activity; heat shock protein binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of release of cytochrome c from mitochondria; and release of cytochrome c from mitochondria. Located in cytosol; membrane; and mitochondrion. Biomarker of intermittent claudication. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]

Bak1 基因产物(1)

mRNA Protein Name
NM_053812.2 NP_446264.1 bcl-2 homologous antagonist/killer
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BH domain binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
12070120 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12454021 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15004018 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
12070120 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
11232245 RGD
involved in endocrine pancreas development IEP
IEP: 通过表达模式推断
11000281 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18349538 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
18349538 RGD
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
12485416 RGD
involved in release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
18252800 RGD
involved in response to UV-C IEP
IEP: 通过表达模式推断
19520675 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
20028358 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
19143845 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18817839 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15875735 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bak1 蛋白结构

Bcl-2_like

Bcl-2_like: cd06845 (26 - 180)

  • 0
  • 100
  • 209 a.a.
蛋白主名 其他名称

bcl-2 homologous antagonist/killer

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01357 BAK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01358 Bak1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01359 Bak1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-129461 Dibenzyl trisulfide Inducer / 否
HY-136999 7-O-Methyleucomol / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bak1 NCBI NCBI:578
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