Eed - embryonic ectoderm development Gene

种属: Mus musculus

同用名: lusk; l7Rn5; l(7)5Rn

基因 ID: 13626 | 基因类型: protein coding

关于 Eed

功能概要

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of adaxial/abaxial pattern formation; and regulation of gene expression. Located in pronucleus and sex chromatin. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including branchial arch; early embryo; extraembryonic component; genitourinary system; and nervous system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Apr 2022]

Eed 基因产物(1)

mRNA	Protein	Name
NM_021876.3	NP_068676.1	polycomb protein EED

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	16687444	MGI
enables enzyme activator activity	IMP IMP: 通过突变表型推断	15916951	MGI
enables methylated histone binding	IDA IDA: 通过直接分析推断	17107999	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9584197	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: 通过表达模式推断	20439489	MGI
involved in facultative heterochromatin formation	IDA IDA: 通过直接分析推断	20064375	MGI
acts upstream of or within genomic imprinting	IMP IMP: 通过突变表型推断	12627233	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	17107999	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	24105743	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: 通过突变表型推断	28041882	MGI
acts upstream of or within regulation of adaxial/abaxial pattern formation	IGI IGI: 通过遗传相互作用推断	17107999	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ESC/E(Z) complex	IDA IDA: 通过直接分析推断	20064375	MGI
part of chromatin silencing complex	IDA IDA: 通过直接分析推断	26658965	MGI
located in nucleus	IDA IDA: 通过直接分析推断	9584197	MGI
located in pronucleus	IDA IDA: 通过直接分析推断	12900441	MGI
located in sex chromatin	IDA IDA: 通过直接分析推断	15525528	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

polycomb protein EED

lethal, Chr 7, Rinchik 5

Eed 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188-1	X-Ray Diffraction	17937919
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188-1	GMS	17937919
种属内	Eed	Q921E6	Jarid2	Mus musculus	Q62315	Density Sedimentation	20064375
种属内	Eed	Q921E6	Jarid2	Mus musculus	Q62315	Anti Tag CoIP	20064376
种属内	Eed	Q921E6	Jarid2	Mus musculus	Q62315	GMS	20075857
种属内	Eed	Q921E6	Jarid2	Mus musculus	Q62315	Anti Tag CoIP	20064375
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188	CoIP	9742080
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188	Density Sedimentation	20064375
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188	Anti Tag CoIP	20064376
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188	IF	12900441
种属内	Eed	Q921E6	Ezh2	Mus musculus	Q61188	Anti Tag CoIP	20064375

种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase

生物活性分子 (4)

目录号	产品名	作用方式	纯度	Phase
HY-103663	MAK683	Inhibitor	99.18%	Phase 2
HY-139400	Pociredir	Inhibitor	99.97%	Phase 1
HY-158102	ORIC-944	Inhibitor	99.90%	Phase 1
HY-139400A	Pociredir hydrochloride	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

生物活性分子 (31)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101117	EED226	Inhibitor	99.65%	否
HY-101512	A-395	Inhibitor	99.12%	否
HY-130708	UNC6852	Inhibitor	99.09%	否
HY-130979	EED226-COOH		98.53%	否
HY-130815A	MAK683-CH2CH2COOH hydrochloride	Inhibitor	98.03%	否
HY-W014099	Boc-NH-C4-acid		99.85%	否
HY-130615	PROTAC EED degrader-2	Inhibitor	99.90%	否
HY-136977	EEDi-5285	Inhibitor	99.98%	否
HY-130614	PROTAC EED degrader-1	Inhibitor	98.27%	否
HY-W004697	Boc-GABA-OH		≥98.0%	否
HY-132922	EEDi-5273	Inhibitor	99.09%	否
HY-157164	PROTAC EZH2 Degrader-2	Degrader	99.78%	否
HY-158102A	ORIC-944 TFA	Inhibitor	/	否
HY-158239	MS181	Inhibitor	98.36%	否
HY-114176B	(S,R,S)-AHPC-C4-NH2 dihydrochloride		/	否
HY-132970	EED ligand 1	Inhibitor	99.93%	否
HY-130815	MAK683-CH2CH2COOH	Inhibitor	/	否
HY-130816	(S,R,S)-AHPC-O-Ph-PEG1-NH2		96.97%	否
HY-114176	(S,R,S)-AHPC-C4-NH2 hydrochloride		≥97.0%	否
HY-103663A	MAK683 hydrochloride	Inhibitor	/	否
HY-130711A	(S,R,S)-AHPC-C3-NH2 TFA		/	否
HY-114176A	(S,R,S)-AHPC-C4-NH2		/	否
HY-130638	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc		/	否
HY-130711	(S,R,S)-AHPC-C3-NH2		/	否
HY-130637	Boc-NH-PEG1-Ph-O-CH2COOH		/	否
HY-130711C	(S,R,S)-AHPC-C3-NH2 dihydrochloride		/	否
HY-160924	MS147	Inhibitor	/	否
HY-P2266	SAH-EZH2	Inhibitor	/	否
HY-RS04173	EED Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-124660A	A-395N		/	否
HY-135045	(S,R,S)-AHPC-C4-COOH		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Eed	NCBI	NCBI:8726

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