Ephb2 - Eph receptor B2 Gene

种属: Mus musculus

同用名: Drt; Erk; Nuk; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5

基因 ID: 13844 | 基因类型: protein coding

关于 Ephb2

功能概要

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Ephb2 基因产物(2)

mRNA	Protein	Name
NM_001290753.2	NP_001277682.1	ephrin type-B receptor 2 isoform 1 precursor
NM_010142.4	NP_034272.1	ephrin type-B receptor 2 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables amyloid-beta binding	IPI IPI: 通过物理相互作用推断	21113149	MGI
enables axon guidance receptor activity	IDA IDA: 通过直接分析推断	11532925	MGI
enables ephrin receptor activity	IDA IDA: 通过直接分析推断	11780069	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16977320	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9883737	MGI
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	9883737	MGI
enables protein tyrosine kinase activity	IMP IMP: 通过突变表型推断	21113149	MGI
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	21113149	MGI
enables signaling receptor activity	IDA IDA: 通过直接分析推断	11780069	MGI
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	11754835	MGI
enables transmembrane-ephrin receptor activity	IDA IDA: 通过直接分析推断	21029865	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiogenesis	IMP IMP: 通过突变表型推断	9990854	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: 通过突变表型推断	15223334	MGI
acts upstream of or within axon guidance	IDA IDA: 通过直接分析推断	11532925	MGI
involved in axon guidance	IMP IMP: 通过突变表型推断	8947026	MGI
involved in axonal fasciculation	IMP IMP: 通过突变表型推断	8947026	MGI
acts upstream of axonogenesis	IDA IDA: 通过直接分析推断	12971893	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: 通过突变表型推断	12971893	MGI
acts upstream of or within cell morphogenesis	IGI IGI: 通过遗传相互作用推断	17686994	MGI
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: 通过直接分析推断	14988728	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IMP IMP: 通过突变表型推断	12971893	MGI
involved in commissural neuron axon guidance	IMP IMP: 通过突变表型推断	8689685	MGI
involved in corpus callosum development	IMP IMP: 通过突变表型推断	8947026	MGI
involved in dendritic spine development	IMP IMP: 通过突变表型推断	14691139	MGI
acts upstream of or within dendritic spine morphogenesis	IDA IDA: 通过直接分析推断	17310244	MGI
involved in dendritic spine morphogenesis	IMP IMP: 通过突变表型推断	14691139	MGI
acts upstream of or within ephrin receptor signaling pathway	IDA IDA: 通过直接分析推断	17310244	MGI
involved in ephrin receptor signaling pathway	IDA IDA: 通过直接分析推断	21029865	MGI
involved in inner ear morphogenesis	IMP IMP: 通过突变表型推断	10839360	MGI
acts upstream of or within learning	IMP IMP: 通过突变表型推断	11754835	MGI
involved in learning or memory	IGI IGI: 通过遗传相互作用推断	21113149	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	11585923	MGI
involved in negative regulation of NMDA glutamate receptor activity	IMP IMP: 通过突变表型推断	21113149	MGI
involved in negative regulation of Ras protein signal transduction	IDA IDA: 通过直接分析推断	11585923	MGI
acts upstream of or within negative regulation of axonogenesis	IDA IDA: 通过直接分析推断	12971893	MGI
acts upstream of negative regulation of protein kinase activity	IDA IDA: 通过直接分析推断	11585923	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	11585923	MGI
involved in neuron projection retraction	IDA IDA: 通过直接分析推断	11585923	MGI
acts upstream of or within optic nerve morphogenesis	IMP IMP: 通过突变表型推断	12971893	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	17686994	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	21029865	MGI
involved in peptidyl-tyrosine phosphorylation	IMP IMP: 通过突变表型推断	21113149	MGI
involved in phosphorylation	IDA IDA: 通过直接分析推断	9883737	MGI
involved in positive regulation of NMDA glutamate receptor activity	IMP IMP: 通过突变表型推断	21113149	MGI
acts upstream of or within positive regulation of long-term neuronal synaptic plasticity	IMP IMP: 通过突变表型推断	11754836	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: 通过突变表型推断	21113149	MGI
involved in positive regulation of synapse assembly	IDA IDA: 通过直接分析推断	21029865	MGI
involved in positive regulation of synapse assembly	IMP IMP: 通过突变表型推断	14691139	MGI
involved in positive regulation of synaptic plasticity	IGI IGI: 通过遗传相互作用推断	21113149	MGI
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	12971893	MGI
acts upstream of or within regulation of axonogenesis	IDA IDA: 通过直接分析推断	14988728	MGI
involved in regulation of body fluid levels	IMP IMP: 通过突变表型推断	10839360	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: 通过突变表型推断	11754835	MGI
involved in regulation of synapse assembly	EXP EXP: 通过实验结果推断	17122040	MGI
involved in regulation of synapse assembly	IDA IDA: 通过直接分析推断	17122040	MGI
involved in regulation of synapse assembly	IMP IMP: 通过突变表型推断	17122040	MGI
acts upstream of or within retinal ganglion cell axon guidance	IDA IDA: 通过直接分析推断	12971893	MGI
involved in roof of mouth development	IMP IMP: 通过突变表型推断	8947026	MGI
involved in urogenital system development	IMP IMP: 通过突变表型推断	15223334	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axon	IDA IDA: 通过直接分析推断	8689685	MGI
located in dendrite	IDA IDA: 通过直接分析推断	14691139	MGI
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	17122040	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	17122040	MGI
is active in glutamatergic synapse	IEP IEP: 通过表达模式推断	18410519	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	17122040	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: 通过直接分析推断	30185604	MGI
located in neuronal cell body	IDA IDA: 通过直接分析推断	12971893	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	8689685	MGI
is active in postsynaptic membrane	IDA IDA: 通过直接分析推断	18410519	MGI
is active in postsynaptic membrane	IEP IEP: 通过表达模式推断	18410519	MGI
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	18410519	MGI
is active in presynaptic membrane	IEP IEP: 通过表达模式推断	18410519	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

ephrin type-B receptor 2

neural kinase	nuk receptor tyrosine kinase
tyrosine-protein kinase receptor EPH-3	tyrosine-protein kinase receptor SEK-3

Ephb2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Ephb2	P54763	TIAM1	Homo sapiens	Q13009	Anti Tag CoIP	17440041
种属内	Ephb2	P54763	TIAM1	Homo sapiens	Q13009	Pull Down	17440041
种属内	Ephb2	P54763	P12023-PRO_0000000118	Mus musculus	P12023-PRO_0000000118	Anti Bait CoIP	21113149
种属内	Ephb2	P54763	P12023-PRO_0000000118	Mus musculus	P12023-PRO_0000000118	Pull Down	21113149
种属内	Ephb2	P54763	P12023-PRO_0000000118	Mus musculus	P12023-PRO_0000000118	Anti Tag CoIP	21113149
种属内	Ephb2	P54763	Epha4	Mus musculus	Q03137	Protein Kinase Assay	16977320
种属内	Ephb2	P54763	Arhgef15	Mus musculus	Q5FWH6-2	Anti Tag CoIP	21029865
种属内	Ephb2	P54763	Src	Mus musculus	P05480	IF	16298995
种属内	Ephb2	P54763	Src	Mus musculus	P05480	Anti Bait CoIP	16298995
种属内	Ephb2	P54763	Efnb2	Mus musculus	P52800	X-Ray Diffraction	11780069
种属内	Ephb2	P54763	Ephb2	Mus musculus	P54763	X-Ray Diffraction	16977320
种属内	Ephb2	P54763	Ptk2	Mus musculus	P34152	Anti Bait CoIP	16298995
种属内	Ephb2	P54763	Grip1	Mus musculus	Q925T6	Y2H	9883737
种属内	Ephb2	P54763	Ephb2	Mus musculus	P54763	NMR	16977320
种属内	Ephb2	P54763	Ptk2	Mus musculus	P34152	IF	16298995

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Ephb2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75235	EphB2 Protein, Mouse (HEK293, His)	P54763-3 (V19-K540)	≥95%
HY-P75236	EphB2 Protein, Mouse (HEK293, Fc)	P54763-3/NP_034272.1 (V19-K540)	≥95%

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-18833	ALW-II-49-7	Inhibitor	99.80%	否
HY-146375	UniPR505	Antagonist	/	否
HY-157019	UniPR1447	Antagonist	/	否
HY-P10630	Pep63	Inhibitor	/	否
HY-RS04434	EPHB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990405	Anti-EphB2 Antibody	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ephb2	NCBI	NCBI:2048
Macaca fascicularis	Ephb2	NCBI	NCBI:102137932

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Ephb2 - Eph receptor B2 Gene

关于 Ephb2

功能概要

Ephb2 基因产物(2)

Ephb2 蛋白互作信息

重组 Ephb2 蛋白

直系同源

热门区域

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Ephb2 - Eph receptor B2 Gene

关于 Ephb2

功能概要

Ephb2 基因产物(2)

Ephb2 蛋白互作信息

重组 Ephb2 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z