Erbb2 - erb-b2 receptor tyrosine kinase 2 Gene

中文名称：erb-b2 受体酪氨酸激酶2

种属: Mus musculus

同用名: Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023

关于 Erbb2

功能概要

预计该基因编码的蛋白具有多种功能，包括 ErbB-3 类受体结合活性； HSP90 蛋白结合活性；和酶结合活性。预计有助于生长因子结合活性。参与 GTPase 活性的正向调节和蛋白质磷酸化的正向调节。在几个过程的上游或内部起作用，包括胸腺中未成熟 T 细胞增殖的负调节；神经系统发育；和神经肌肉接头发育。位于顶端质膜；细胞质囊泡；和髓鞘。以多种结构表达，包括肾上腺；消化系统；中枢神经系统;泌尿生殖系统；和感觉器官。用于研究先天性巨结肠；乳腺癌;和扩张型心肌病。该基因的人类直系同源物与癌症有关（多个）；高级别神经胶质瘤；生殖器官癌（多发性）；和膀胱癌。与人 ERBB2（erb-b2 受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ErbB-3 class receptor binding activity; HSP90 protein binding activity; and Enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]