2. Gene
  3. ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：erb-b2 受体酪氨酸激酶2

种属: Rattus norvegicus

同用名: neu; HER2/neu

基因 ID: 24337 | 基因类型: protein coding

关于 ERBB2

Primary_assembly 10: 83,411,313-83,435,078 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 54 paralogues and is associated with 83 phenotypes. Biased expression in Kidney (RPKM 121.3), Lung (RPKM 59.5) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 HSP90 蛋白结合活性；蛋白酪氨酸激酶活性；和泛素蛋白连接酶结合活性。参与多个过程，包括动物器官发育；神经系统发育；和细胞内信号转导的正调控。位于几种细胞成分中，包括基底外侧质膜；侧环;和微绒毛。充血性心力衰竭和正中神经病变的生物标志物。该基因的人类直系同源物与癌症有关（多个）；扩张型心肌病;高级别神经胶质瘤；生殖器官癌（多发性）；和膀胱癌。与人 ERBB2（erb-b2 受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables HSP90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

ERBB2 基因产物(1)

mRNA Protein Name
NM_017003.2 NP_058699.2 receptor tyrosine-protein kinase erbB-2 precursor

ERBB2 蛋白结构

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 176)

Furin-like

Furin-like: pfam00757 (192 - 341)

Recep_L_domain

Recep_L_domain: pfam01030 (369 - 485)

GF_recep_IV

GF_recep_IV: pfam14843 (513 - 646)

TM_ErbB2

TM_ErbB2: cd12094 (644 - 687)

PTKc_HER2

PTKc_HER2: cd05109 (715 - 993)

PHA03247

PHA03247: cl33720 (1036 - 1218)

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  • 1259 a.a.
蛋白主名 其他名称

receptor tyrosine-protein kinase erbB-2

Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)

C-erbB-2

NEU proto-oncogene

epidermal growth factor receptor-related protein

p185erbB2

p185neu

proto-oncogene NEU

proto-oncogene c-ErbB-2

receptor tyrosine-protein kinase erbB-2-like

v-erb-b2 avian erythroblastic leukemia viral oncogene 2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

重组 ERBB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72626 HER2/CD340 Protein, Rat (His) P06494 (A67-V323) ≥95%
HY-P73097 HER2/CD340 Protein, Rat (HEK293) Q8K3F9 (M4-T656) ≥95%
HY-P74895 HER2/CD340 Protein, Rat (HEK293, His) AAH61863 (M4-T656) ≥95%
HY-P74896 HER2/CD340 Protein, Rat (HEK293, Fc) AAH61863 (M4-T656) ≥95%

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50898 Lapatinib 99.83% 是
HY-13272 Dacomitinib 99.74% 是
HY-50898A Lapatinib ditosylate 99.98% 是
HY-50898B Lapatinib ditosylate monohydrate 99.78% 是
HY-50898C Lapatinib tosylate / 否
Clinical Phase
生物活性分子 (12)
目录号 产品名 作用方式
纯度 Phase
HY-13314 Tesevatinib Inhibitor 99.21% Phase 3
HY-16069A Tucatinib hemiethanolate Inhibitor 99.97% Phase 3
HY-13050 Sapitinib Inhibitor 99.93% Phase 2
HY-10367 Canertinib Inhibitor 99.82% Phase 2
HY-32718 Pelitinib Inhibitor 98.80% Phase 2
HY-10045 AEE788 99.13% Phase 2
HY-10367A Canertinib dihydrochloride Inhibitor 99.68% Phase 2
HY-10322 Falnidamol Inhibitor 99.05% Phase 1
HY-103443 HKI-357 Inhibitor 99.65% Phase 1
HY-10346A AV-412 free base Inhibitor 98.33% Phase 1
HY-116437 Selatinib Inhibitor 99.83% Phase 1
HY-10346 AV-412 Inhibitor 99.17% Phase 1
Pre-clinical Phase
生物活性分子 (37)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13896 PD168393 98.58% 否
HY-18609 PD158780 Inhibitor 99.56% 否
HY-14674 CP-724714 98.53% 否
HY-15844 AG-825 98.02% 否
HY-13427 Allitinib tosylate Inhibitor 99.83% 否
HY-20878 Tyrphostin AG 879 99.85% 否
HY-135366 HPN-01 Inhibitor 98.61% 否
HY-N1166 Tephrosin 98.02% 否
HY-W006886 Fmoc-(R)-2-(7-octenyl)Ala-OH / 否
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 98.19% 否
HY-150023 BI-1622 Inhibitor 98.97% 否
HY-100499 Tyrphostin AG 528 Inhibitor ≥98.0% 否
HY-101042 AG-494 Inhibitor 99.31% 否
HY-112420 EGFR/ErbB-2/ErbB-4 inhibitor-2 Inhibitor 99.45% 否
HY-103441 JNJ28871063 hydrochloride Inhibitor 98.36% 否
HY-50898S Lapatinib-d4 99.02% 否
HY-103439 GW583340 dihydrochloride Inhibitor / 否
HY-13272S2 Dacomitinib-d10 dihydrochloride ≥95.0% 否
HY-15375 Allitinib Inhibitor 99.36% 否
HY-147407 Imbotolimod / 否
HY-123035 Gamendazole Inhibitor / 否
HY-13050A Sapitinib fumarate Inhibitor / 否
HY-13272S3 Dacomitinib-d10 / 否
HY-137028 2′-Thioadenosine Inhibitor / 否
HY-156639 EGFR/ErbB-2 inhibitor-1 Inhibitor / 否
HY-160068 2-2(t) aptamer sodium Chemical / 否
HY-50898S1 Lapatinib-d7 dihydrochloride / 否
HY-50898S2 Lapatinib-d5 / 否
HY-50898S3 Lapatinib-d4-1 / 否
HY-P4082 ErbB-2-binding peptide 99.83% 否
HY-RS04466 ERBB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04467 Erbb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04468 ERBB2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W008914 (E/Z)-CP-724714 Inhibitor / 否
HY-103443A HKI-357 dimaleate Inhibitor / 否
HY-129288 GW837016X Inhibitor / 否
HY-164548 WK88-1 / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99558 Timigutuzumab Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ERBB2 NCBI NCBI:2064
Canis familiaris ERBB2 NCBI NCBI:403883
Macaca fascicularis ERBB2 NCBI NCBI:102146608
Mus musculus ERBB2 NCBI NCBI:13866
Macaca mulatta ERBB2 NCBI NCBI:697573
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