1. Gene
  2. ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

中文名称:erb-b2 受体酪氨酸激酶2

种属: Rattus norvegicus

同用名: neu; HER2/neu

基因 ID: 24337 | 基因类型: protein coding

关于 ERBB2

Primary_assembly 10: 83,411,313-83,435,078 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 54 paralogues and is associated with 83 phenotypes. Biased expression in Kidney (RPKM 121.3), Lung (RPKM 59.5) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 HSP90 蛋白结合活性;蛋白酪氨酸激酶活性;和泛素蛋白连接酶结合活性。参与多个过程,包括动物器官发育;神经系统发育;和细胞内信号转导的正调控。位于几种细胞成分中,包括基底外侧质膜;侧环;和微绒毛。充血性心力衰竭和正中神经病变的生物标志物。该基因的人类直系同源物与癌症有关(多个);扩张型心肌病;高级别神经胶质瘤;生殖器官癌(多发性);和膀胱癌。与人 ERBB2(erb-b2 受体酪氨酸激酶 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables HSP90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

ERBB2 基因产物(1)

mRNA Protein Name
NM_017003.2 NP_058699.2 receptor tyrosine-protein kinase erbB-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp90 protein binding IPI
IPI: 通过物理相互作用推断
15671027 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9271418 RGD
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
1359541 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
16168116 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
15671027 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERBB2-ERBB4 signaling pathway IDA
IDA: 通过直接分析推断
19632177 RGD
involved in axon regeneration IMP
IMP: 通过突变表型推断
23437108 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
30813222 RGD
involved in estrous cycle IMP
IMP: 通过突变表型推断
11956173 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
21186272 RGD
involved in glial cell differentiation IGI
IGI: 通过遗传相互作用推断
12853432 RGD
involved in liver development IEP
IEP: 通过表达模式推断
12454858 RGD
involved in mammary gland involution IEP
IEP: 通过表达模式推断
10653587 RGD
involved in multicellular organismal response to stress IEP
IEP: 通过表达模式推断
27133902 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
12673197 RGD
involved in peripheral nervous system development IMP
IMP: 通过突变表型推断
15496447 RGD
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
16168116 RGD
involved in positive regulation of Ras protein signal transduction IMP
IMP: 通过突变表型推断
12673197 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9271418 RGD
involved in positive regulation of membrane permeability IMP
IMP: 通过突变表型推断
30813222 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
16859650 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
16168116 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
1359541 RGD
involved in response to axon injury IDA
IDA: 通过直接分析推断
15800203 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
27133902 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
26892146 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
17459743 RGD
involved in response to vitamin D IEP
IEP: 通过表达模式推断
27209698 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18184445 RGD
involved in skeletal muscle tissue development IEP
IEP: 通过表达模式推断
8846777 RGD
involved in sympathetic nervous system development IMP
IMP: 通过突变表型推断
15496447 RGD
involved in tongue development IEP
IEP: 通过表达模式推断
10908606 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15499570 RGD
located in basal plasma membrane IDA
IDA: 通过直接分析推断
15499570 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
15499570 RGD
located in lateral loop IDA
IDA: 通过直接分析推断
15800203 RGD
located in microvillus IDA
IDA: 通过直接分析推断
15800203 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16859650 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15800203 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
7589796 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ERBB2 蛋白结构

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 176)

Furin-like

Furin-like: pfam00757 (192 - 341)

Recep_L_domain

Recep_L_domain: pfam01030 (369 - 485)

GF_recep_IV

GF_recep_IV: pfam14843 (513 - 646)

TM_ErbB2

TM_ErbB2: cd12094 (644 - 687)

PTKc_HER2

PTKc_HER2: cd05109 (715 - 993)

PHA03247

PHA03247: cl33720 (1036 - 1218)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1259 a.a.
蛋白主名 其他名称

receptor tyrosine-protein kinase erbB-2

Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)

C-erbB-2

NEU proto-oncogene

epidermal growth factor receptor-related protein

p185erbB2

p185neu

proto-oncogene NEU

proto-oncogene c-ErbB-2

receptor tyrosine-protein kinase erbB-2-like

v-erb-b2 avian erythroblastic leukemia viral oncogene 2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

重组 ERBB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72626 HER2/CD340 Protein, Rat (His) P06494 (A67-V323) ≥95%
HY-P73097 HER2/CD340 Protein, Rat (HEK293) AAH61863 (T26-T656, with seven additional amino acids (ALEVLFQ) at the C-terminus) ≥95%
HY-P74895 HER2/CD340 Protein, Rat (HEK293, His) AAH61863 (M4-T656) ≥95%
HY-P74896 HER2/CD340 Protein, Rat (HEK293, Fc) AAH61863 (T26-T656) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ERBB2 NCBI NCBI:2064
Canis familiaris ERBB2 NCBI NCBI:403883
Macaca fascicularis ERBB2 NCBI NCBI:102146608
Mus musculus ERBB2 NCBI NCBI:13866
Macaca mulatta ERBB2 NCBI NCBI:697573