NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

中文名称：notum, 棕榈油酰蛋白羧酸酯酶

种属: Homo sapiens

同用名: hNOTUM

基因 ID: 147111 | 基因类型: protein coding

关于 NOTUM

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,952,507-81,961,187 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Restricted expression toward placenta (RPKM 82.6).

功能概要

启用棕榈油酰水解酶活性。参与 Wnt 信号通路和蛋白质去棕榈油酰化的负调控。在骨发育和骨矿化调节的上游或内部起作用。预测位于内质网腔和细胞外区域。 [由基因组资源联盟提供，2022 年 4 月]

Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

NOTUM 基因产物(1)

mRNA	Protein	Name
NM_178493.6	NP_848588.3	palmitoleoyl-protein carboxylesterase NOTUM precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables palmitoleyl hydrolase activity	IDA IDA: 通过直接分析推断	25731175	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within bone development	IMP IMP: 通过突变表型推断	30622831	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: 通过直接分析推断	25731175	GOA
involved in protein depalmitoleylation	IDA IDA: 通过直接分析推断	25731175	GOA
acts upstream of or within regulation of bone mineralization	IDA IDA: 通过直接分析推断	30622831	GOA
acts upstream of or within regulation of bone mineralization	IMP IMP: 通过突变表型推断	30622831	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOTUM 蛋白结构

PAE

0
100
200
300
400
496 a.a.

蛋白主名

其他名称

palmitoleoyl-protein carboxylesterase NOTUM

[Wnt protein] O-palmitoleoyl-L-serine hydrolase

NOTUM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NOTUM	Q6P988	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
种属内	NOTUM	Q6P988	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
种属内	NOTUM	Q6P988	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NOTUM 蛋白

目录号	产品名	蛋白编号	纯度
HY-P79357	Notum Protein, Human (C330S, CHO, His)	Q6P988 (S81-T451, C330S)	≥95%

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-131034	LP-922056	Activator	≥98.0%	否
HY-122832	ABC99	Inhibitor	99.62%	否
HY-147519	ARUK3001185	Activator	99.16%	否
HY-142689	Carboxylesterase-IN-3	Inhibitor	98.01%	否
HY-142688	Carboxylesterase-IN-2	Inhibitor	99.83%	否
HY-148360	Notum pectinacetylesterase-1		/	否
HY-149818	8BTC	Inhibitor	/	否
HY-RS09454	NOTUM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W171983	Notum-IN-1	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NOTUM	VGNC	VGNC:104636
Bos taurus	NOTUM	VGNC	VGNC:106845
Mus musculus	NOTUM	MGD	MGI:1924833
Felis catus	NOTUM	VGNC	VGNC:63863
Canis familiaris	NOTUM	VGNC	VGNC:43901
Rattus norvegicus	NOTUM	RGD	RGD:1307119
Others	NOTUM	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

关于 NOTUM

功能概要

NOTUM 基因产物(1)

NOTUM 蛋白结构

NOTUM 蛋白互作信息

重组 NOTUM 蛋白

关联疾病

直系同源

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NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

关于 NOTUM

功能概要

NOTUM 基因产物(1)

NOTUM 蛋白结构

NOTUM 蛋白互作信息

重组 NOTUM 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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