2. Gene
  3. GLIS1 - GLIS family zinc finger 1 Gene

GLIS1 - GLIS family zinc finger 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：GLIS 家族锌指 1

种属: Homo sapiens

基因 ID: 148979 | 基因类型: protein coding

关于 GLIS1

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,506,239-53,739,164 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 14 paralogues. Low expression observed in reference dataset.

功能概要

GLIS1 是一种与 Gli (MIM 165220) 相关的 Kruppel 样锌指蛋白，可作为转录的激活剂和抑制因子发挥作用 (Kim 等人，2002 [PubMed 12042312]) 。[OMIM 提供，2008 年 3 月]

GLIS1 is a Gli (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

GLIS1 基因产物(5)

mRNA Protein Name
NM_001367484.1 NP_001354413.1 zinc finger protein GLIS1 isoform 2
NM_001390836.1 NP_001377765.1 zinc finger protein GLIS1 isoform 3
NM_001390837.1 NP_001377766.1 zinc finger protein GLIS1 isoform 2
NM_001390838.1 NP_001377767.1 zinc finger protein GLIS1 isoform 4
NM_147193.4 NP_671726.2 zinc finger protein GLIS1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLIS1 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (249 - 275)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (278 - 305)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (322 - 346)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 620 a.a.
蛋白主名 其他名称

zinc finger protein GLIS1

GLI-similar 1

关联疾病

疾病名称 别名
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Myoclonic Epilepsy Associated With Ragged-Red Fibers

Merrf Syndrome

MERRF

Fukuhara Syndrome

Myoclonic Epilepsy Associated With Ragged Red Fibers

Myoencephalopathy Ragged-Red Fiber Disease

Myoclonic Epilepsy - Ragged Red Fibers

Myoclonus Epilepsy And Ragged Red Fibers

Myoclonus With Epilepsy And With Ragged Red Fibers

Myoclonic Epilepsy With Ragged Red Fibers

Myoclonic Epilepsy With Ragged-Red Fibers

Fukuhara Disease

Myoclonus Epilepsy Associated With Ragged-Red Fibres

Myoclonus With Epilepsy With Ragged Red Fibers
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13901 GANT 61 ≥98.0% 否
HY-13282 GANT 58 Antagonist 99.62% 否
HY-P4860 Adropin (34-76) (human, mouse, rat) 99.87% 否
HY-122590 Glabrescione B Inhibitor 98.05% 否
HY-18366A RU-SKI 43 hydrochloride Inhibitor 99.55% 否
HY-N2112 Glaucocalyxin A 99.39% 否
HY-107551 GLI antagonist-1 Antagonist ≥95% 否
HY-W111144 T-1330 Inhibitor / 否
HY-18366 RU-SKI 43 Inhibitor / 否
HY-137567 Prostaglandin E1 ethanolamide Activator / 否
HY-143400 HSP70-IN-3 Inhibitor / 否
HY-147670 TPB15 / 否
HY-161459 GLI1-IN-1 / 否
HY-162273 Antibacterial agent 189 Inhibitor / 否
HY-N8270 Physalin H Inhibitor / 否
HY-RS05472 GLI1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05473 Gli1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05474 Gli1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05480 GLIS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-122017 Methoxy-SANT-2 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GLIS1 VGNC VGNC:62580
Mus musculus GLIS1 MGD MGI:2386723
Rattus norvegicus GLIS1 RGD RGD:1308030
Macaca mulatta GLIS1 VGNC VGNC:73034
Canis familiaris GLIS1 VGNC VGNC:49872
Bos taurus GLIS1 VGNC VGNC:29406
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