Hdac5 - histone deacetylase 5 Gene

中文名称：组蛋白脱乙酰酶 5

种属: Mus musculus

同用名: HD5; Hdac4; mHDA1; mKIAA0600

关于 Hdac5

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性；转录辅抑制活性；和转录辅阻遏物结合活性。涉及多个过程，包括细胞对流体剪切应力的反应；细胞群增殖的正向调节；和调节肌管分化。作用于多个过程的上游或内部，包括大分子代谢过程的负调节；成骨细胞分化的负调节；和成骨细胞发育。位于多个细胞成分中，包括轴突生长锥；染色质；和核体。 RNA 聚合酶 II 转录抑制复合物的一部分。以多种结构表达，包括中枢神经系统；早期胚胎；头骨;感觉器官；和上臂。与人类 HDAC5（组蛋白脱乙酰酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to fluid shear stress; positive regulation of cell population proliferation; and regulation of myotube differentiation. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; negative regulation of osteoblast differentiation; and osteoblast development. Located in several cellular components, including axonal growth cone; chromatin; and nuclear body. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early embryo; head bone; sensory organ; and upper arm. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]