2. Gene
  3. Smad2 - SMAD family member 2 Gene

Smad2 - SMAD family member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Madh2; Madr2; mMad2; Smad-2; 7120426M23Rik

基因 ID: 17126 | 基因类型: protein coding

关于 Smad2

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and Tau Protein binding activity. Involved in positive regulation of epithelial to mesenchymal transition and secondary palate development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian Cancer. Orthologous to human SMAD2 (Smad Family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smad2 基因产物(3)

mRNA Protein Name
NM_001252481.1 NP_001239410.1 mothers against decapentaplegic homolog 2 isoform 1
NM_001311070.1 NP_001297999.1 mothers against decapentaplegic homolog 2 isoform 2
NM_010754.5 NP_034884.2 mothers against decapentaplegic homolog 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
27336669 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IPI
IPI: 通过物理相互作用推断
24964035 MGI
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
9702197 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11937490 MGI
enables SMAD binding IPI
IPI: 通过物理相互作用推断
11160896 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
15657445 MGI
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
15282343 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21724602 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9702197 MGI
enables tau protein binding IDA
IDA: 通过直接分析推断
24964035 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within SMAD protein signal transduction IGI
IGI: 通过遗传相互作用推断
23390484 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
9529255 MGI
involved in aortic valve morphogenesis IGI
IGI: 通过遗传相互作用推断
23531444 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
12842913 MGI
acts upstream of or within cell population proliferation IGI
IGI: 通过遗传相互作用推断
19679673 MGI
acts upstream of or within developmental growth IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within embryonic foregut morphogenesis IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within embryonic pattern specification IGI
IGI: 通过遗传相互作用推断
15183723 MGI
involved in endocardial cushion morphogenesis IGI
IGI: 通过遗传相互作用推断
23531444 MGI
acts upstream of or within endoderm development IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within endoderm formation IMP
IMP: 通过突变表型推断
21822279 MGI
acts upstream of or within gastrulation IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within in utero embryonic development IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
17849440 MGI
acts upstream of or within insulin secretion IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: 通过直接分析推断
14749725 MGI
acts upstream of or within lung development IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within mesoderm formation IMP
IMP: 通过突变表型推断
15084457 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: 通过突变表型推断
23152446 MGI
involved in odontoblast differentiation IMP
IMP: 通过突变表型推断
33548622 MGI
acts upstream of or within organ growth IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within pancreas development IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within paraxial mesoderm morphogenesis IMP
IMP: 通过突变表型推断
15084457 MGI
acts upstream of or within pattern specification process IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within pericardium development IGI
IGI: 通过遗传相互作用推断
15183723 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15282343 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
14691138 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
14691138 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
23152446 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9702197 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17159989 MGI
acts upstream of or within post-embryonic development IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
18990706 MGI
involved in pulmonary valve morphogenesis IGI
IGI: 通过遗传相互作用推断
23531444 MGI
acts upstream of or within regulation of binding IDA
IDA: 通过直接分析推断
15282343 MGI
acts upstream of or within response to glucose IGI
IGI: 通过遗传相互作用推断
17849440 MGI
acts upstream of or within response to transforming growth factor beta IGI
IGI: 通过遗传相互作用推断
19679673 MGI
involved in secondary palate development IMP
IMP: 通过突变表型推断
14691138 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
11557747 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
18212064 MGI
involved in ureteric bud development IEP
IEP: 通过表达模式推断
14656760 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14691138 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11160896 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
9702197 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 2

MAD homolog 2

Smad 2

mad-related protein 2

mothers against DPP homolog 2

重组 Smad2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73637 SMAD2 Protein, Mouse (sf9, His-GST) Q62432 (S2-S467) ≥95%

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99720 Luspatercept Inhibitor 98.92% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-N2037A Higenamine hydrochloride 99.68% Phase 1
HY-N2037 Higenamine 98.91% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99351 Andecaliximab Inhibitor 95.00% Phase 3
Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116084 Trimethylamine N-oxide Activator ≥98.0% 否
HY-100830 NCB-0846 Inhibitor 99.61% 否
HY-108915 Trimethylamine N-oxide dihydrate Activator ≥98.0% 否
HY-116084S Trimethylamine N-oxide-d9 Activator 99.76% 否
HY-100444 SIS3 free base Inhibitor 98.11% 否
HY-123900 AZ12799734 Inhibitor 98.07% 否
HY-144043 ALK5-IN-8 Inhibitor 98.06% 否
HY-18766 EW-7195 Inhibitor 99.20% 否
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% 否
HY-122856 AZ12601011 Inhibitor 99.88% 否
HY-100448A Butaprost 99.00% 否
HY-N4107 Phyllanthin Inhibitor 99.96% 否
HY-P10414A Klotho-derived peptide 1 hydrochloride Inhibitor 97.28% 否
HY-100830A NCB-0970 Control / 否
HY-116084S1 Trimethylamine-N-oxide-13C3 Activator / 否
HY-149136 MORF-627 Inhibitor / 否
HY-161398 TGFβRII-IN-3 / 否
HY-162404 Smad2/3-IN-2 Inhibitor / 否
HY-162405 Smad2/3-IN-1 Inhibitor / 否
HY-168607 ALK5-IN-83 Inhibitor / 否
HY-170578 SIRT2-IN-17 Inhibitor / 否
HY-P10363 Tiger17 Activator / 否
HY-P10414 Klotho-derived peptide 1 Inhibitor / 否
HY-RS13393 SMAD2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-118528 TP0427736 Inhibitor / 否
HY-N2037AS1 Higenamine-d4-1 hydrochloride / 否
HY-W108953 Myristoyl tetrapeptide-12 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad2 NCBI NCBI:4087
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