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  2. AFM - afamin Gene

AFM - afamin Gene

中文名称:阿法明

种属: Homo sapiens

同用名: ALF; ALB2; ALBA

基因 ID: 173 | 基因类型: protein coding

关于 AFM

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,481,745-73,504,001 (from NCBI)

This gene has 2 transcripts (splice variants), 135 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 187.4).

功能概要

该基因是白蛋白基因家族的成员,该家族由四个基因组成,这些基因串联排列在 4 号染色体上。这四个基因编码结构相关的血清转运蛋白,这些蛋白已知在进化上相关。由该基因编码的蛋白质在发育过程中受到调节,在肝脏中表达并分泌到血液中。[RefSeq 提供,2008 年 7 月]

This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]

AFM 基因产物(1)

mRNA Protein Name
NM_001133.2 NP_001124.1 afamin precursor

AFM 蛋白结构

Serum_albumin

Serum_albumin: Serum albumin family (31 - 202)

Serum_albumin

Serum_albumin: Serum albumin family (220 - 394)

Serum_albumin

Serum_albumin: Serum albumin family (413 - 590)

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  • 599 a.a.
蛋白主名 其他名称

afamin

alpha-Alb

重组 AFM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70036 Afamin/AFM Protein, Human (HEK293, His) P43652 (L22-N599) ≥95%
HY-P70036A Afamin/AFM Protein, Human (599a.a, HEK293, His) P43652 (M1-N599) ≥95%
HY-P70036B Afamin/AFM Protein, Human (578a.a, HEK293, C-His) P43652 (L13-N599) ≥95%

关联疾病

疾病名称 别名
Squamous Papillomatosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AFM VGNC VGNC:69740
Bos taurus AFM VGNC VGNC:25715
Canis familiaris AFM VGNC VGNC:37691
Mus musculus AFM MGD MGI:2429409
Rattus norvegicus AFM RGD RGD:628614
Others AFM NCBI