Mmp13 - matrix metallopeptidase 13 Gene

中文名称：基质金属肽酶 13

种属: Mus musculus

同用名: Clg; Mmp1; MMP-13

关于 Mmp13

功能概要

该基因编码基质金属蛋白酶家族的一个成员，该家族在伤口愈合、骨骼发育和骨重塑中发挥作用。编码的蛋白质通过去除 N 末端激活肽而被激活，以产生锌依赖性肽链内切酶，该酶可以切割各种天然胶原蛋白，包括 I-IV、X 和 XIV 型。缺乏编码蛋白的小鼠在生长板软骨中表现出严重缺陷以及软骨内骨发育延迟。由于伤口部位的角质形成细胞迁移和血管密度减少，编码蛋白的缺乏也会损害伤口愈合过程。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供，2015 年 6 月]

This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase Enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]