1. Gene
  2. Nrtn - neurturin Gene

Nrtn - neurturin Gene

种属: Mus musculus

同用名: NTN

基因 ID: 18188 | 基因类型: protein coding

关于 Nrtn

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016]

Nrtn 基因产物(1)

mRNA Protein Name
NM_008738.3 NP_032764.1 neurturin preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth factor activity IDA
IDA: 通过直接分析推断
8945474 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway IGI
IGI: 通过遗传相互作用推断
9576965 MGI
involved in glial cell-derived neurotrophic factor receptor signaling pathway IDA
IDA: 通过直接分析推断
8945474 MGI
acts upstream of or within nerve development IMP
IMP: 通过突变表型推断
10069332 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
8945474 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

neurturin

重组 Nrtn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700224AF Animal-Free Neurturin Protein, Mouse (His) P97463.1 (P96-V195) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nrtn NCBI NCBI:4902