2. Gene
  3. Musk - muscle, skeletal, receptor tyrosine kinase Gene

Musk - muscle, skeletal, receptor tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mlk; Mdk4; Nsk1; Nsk2; Nsk3

基因 ID: 18198 | 基因类型: protein coding

关于 Musk

功能概要

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Musk 基因产物(6)

mRNA Protein Name
NM_001037127.2 NP_001032204.2 muscle, skeletal receptor tyrosine-protein kinase isoform 1
NM_001037128.1 NP_001032205.1 muscle, skeletal receptor tyrosine-protein kinase isoform 2
NM_001037129.1 NP_001032206.1 muscle, skeletal receptor tyrosine-protein kinase isoform 3
NM_001037130.1 NP_001032207.1 muscle, skeletal receptor tyrosine-protein kinase isoform 5
NM_001165996.1 NP_001159468.1 muscle, skeletal receptor tyrosine-protein kinase isoform 6
NM_010944.2 NP_035074.2 muscle, skeletal receptor tyrosine-protein kinase isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
17576800 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12165471 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
14622576 MGI
enables protein tyrosine kinase activity IGI
IGI: 通过遗传相互作用推断
14622576 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
8653787 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: 通过直接分析推断
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: 通过遗传相互作用推断
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: 通过突变表型推断
14622576 MGI
acts upstream of motor neuron apoptotic process IMP
IMP: 通过突变表型推断
11312299 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: 通过遗传相互作用推断
12165471 MGI
involved in positive regulation of Rac protein signal transduction IDA
IDA: 通过直接分析推断
16794080 MGI
involved in positive regulation of Rac protein signal transduction IGI
IGI: 通过遗传相互作用推断
14622576 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: 通过突变表型推断
8653787 MGI
acts upstream of or within positive regulation of motor neuron apoptotic process IMP
IMP: 通过突变表型推断
11312299 MGI
involved in positive regulation of protein geranylgeranylation IMP
IMP: 通过突变表型推断
14622576 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
14622576 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: 通过直接分析推断
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: 通过遗传相互作用推断
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
14622576 MGI
acts upstream of or within receptor clustering IGI
IGI: 通过遗传相互作用推断
12165471 MGI
acts upstream of or within receptor clustering IMP
IMP: 通过突变表型推断
11395002 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
10320756 MGI
acts upstream of or within regulation of synaptic assembly at neuromuscular junction IMP
IMP: 通过突变表型推断
8653786 MGI
involved in skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
11323662 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
20053883 MGI
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
14622576 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
17119023 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
14678832 MGI
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
9136771 MGI
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
19038220 MGI
located in synapse IDA
IDA: 通过直接分析推断
20053883 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

muscle, skeletal receptor tyrosine-protein kinase

muscle localized kinase 2

muscle-specific kinase receptor

muscle-specific tyrosine-protein kinase receptor

Musk 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Musk Q61006 Dok7 Mus musculus Q18PE0
X-Ray Diffraction
20603078
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Musk 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71568 MUSK Protein, Mouse (Myc, His-SUMO) Q61006 (E22-S494) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0633 Muscone Inhibitor ≥98.0% 否
HY-15590 AZ-23 Inhibitor 98.92% 否
HY-N2045 Musk ketone 99.41% 否
HY-N3127 Orobol Inhibitor 99.28% 否
HY-116108 Musk tibetene / 否
HY-RS08852 MUSK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Musk NCBI NCBI:4593
Macaca fascicularis Musk NCBI NCBI:102127677
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