2. Gene
  3. Pde1a - phosphodiesterase 1A, calmodulin-dependent Gene

Pde1a - phosphodiesterase 1A, calmodulin-dependent Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 1A，钙调蛋白依赖性

种属: Mus musculus

基因 ID: 18573 | 基因类型: protein coding

关于 Pde1a

Chromosome 2: 79,664,797-79,959,802 reverse strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 208 orthologues, 20 paralogues and is associated with 15 phenotypes. Biased expression in cortex adult (RPKM 19.1), frontal lobe adult (RPKM 12.1) and 8 other tissues.

功能概要

该基因编码的蛋白可启动钙和钙调蛋白调节的 3',5'-环 GMP 磷酸二酯酶活性。预计参与信号转导。预测在神经细胞体中有活性。以多种结构表达，包括消化系统；脑;泌尿生殖系统；外皮系统；和感觉器官。与人 PDE1A（磷酸二酯酶 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in signal transduction. Predicted to be active in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Pde1a 基因产物(8)

mRNA Protein Name
NM_001009979.1 NP_001009979.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_001355142.2 NP_001342071.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 12
NM_016744.4 NP_058024.2 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001355140.1 NP_001342069.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001355144.1 NP_001342073.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 13
NM_001355141.1 NP_001342070.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001009978.1 NP_001009978.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7
NM_001159582.1 NP_001153054.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
15901640 MGI
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
15901640 MGI
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
15901640 MGI
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
15901640 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in sperm flagellum IDA
IDA: 通过直接分析推断
15901640 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde1a 蛋白结构

PDEase_I_N

PDEase_I_N: pfam08499 (72 - 132)

PDEase_I

PDEase_I: pfam00233 (217 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 545 a.a.
蛋白主名 其他名称

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

61 kDa Cam-PDE

cam-PDE 1A

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-12501A ITI-214 Inhibitor 99.19% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-12501 ITI-214 free base Inhibitor ≥98.0% Phase 2
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101490 PDE1-IN-2 Inhibitor ≥98.0% 否
HY-136569 DSR-141562 Inhibitor 99.98% 否
HY-120741 PF-04822163 Inhibitor / 否
HY-147946 PDE1-IN-4 Inhibitor / 否
HY-RS10208 PDE1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10209 Pde1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10210 PDE1A Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde1a NCBI NCBI:5136
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