Prkca - protein kinase C, alpha Gene

中文名称：蛋白激酶 C， α

种属: Mus musculus

同用名: Pkca

关于 Prkca

功能概要

该基因编码的蛋白可启动钙依赖性蛋白激酶 C 活性和整合素结合活性。涉及多个过程，包括化学突触传递的调节；正向调节骨吸收；和致密核心颗粒生物发生的正调控。在几个过程的上游或内部起作用，包括诱导正趋化性；信号转导的负调控；和蛋白质磷酸化的调节。位于几种细胞成分中，包括 Held 的花萼；闰盘;和光感受器外段。 alphav-beta3 整合素-PKCalpha 复合物的一部分。在突触前细胞质中活跃。以多种结构表达，包括消化系统；脑;早期胚胎；泌尿生殖系统；和感觉器官。该基因的人类直系同源物与扩张型心肌病有关；高级别神经胶质瘤（多发）；大细胞癌；和生殖器官癌（多发性）。与人 PRKCA（蛋白激酶 C α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium-dependent protein kinase C activity and Integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including calyx of Held; intercalated disc; and photoreceptor outer segment. Part of alphav-beta3 integrin-PKCalpha complex. Is active in presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]