TIGIT - T cell immunoreceptor with Ig and ITIM domains Gene

中文名称：具有 Ig 和 ITIM 结构域的 T 细胞免疫受体

种属: Homo sapiens

同用名: VSIG9; VSTM3; WUCAM

基因 ID: 201633 | 基因类型: protein coding

关于 TIGIT

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:114,294,028-114,310,288 (from NCBI)

This gene has 7 transcripts (splice variants), 618 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 15.1), spleen (RPKM 5.9) and 7 other tissues.

功能概要

该基因编码免疫球蛋白 PVR (脊髓灰质炎病毒受体) 家族的成员。该基因的产物在几类 T 细胞上表达，包括滤泡 B 辅助性 T 细胞 (TFH) 。该蛋白已被证明能以高亲和力结合 PVR；这种结合被认为有助于 TFH 和树突细胞之间的相互作用，以调节依赖于 T 细胞的 B 细胞反应。[RefSeq 提供，2009 年 9 月]

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

TIGIT 基因产物(1)

mRNA	Protein	Name
NM_173799.4	NP_776160.2	T-cell immunoreceptor with Ig and ITIM domains precursor

TIGIT 蛋白结构

V-set

0
100
200
244 a.a.

蛋白主名

其他名称

T-cell immunoreceptor with Ig and ITIM domains

V-set and immunoglobulin domain containing 9

TIGIT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TIGIT	Q495A1	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
种属内	TIGIT	Q495A1	PVR	Homo sapiens	P15151	SPR	28515320
种属内	TIGIT	Q495A1	CD226	Homo sapiens	Q15762	FRET	25465800
种属内	TIGIT	Q495A1	PVR	Homo sapiens	P15151-1	SPR	27978489
种属内	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	SPR	28515320
种属内	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	Protein Array	21982860
种属内	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	SPR	27978489
种属内	TIGIT	Q495A1	TIGIT	Homo sapiens	Q495A1	X-Ray Diffraction	27978489
种属内	TIGIT	Q495A1	TIGIT	Homo sapiens	Q495A1	GMS	27978489
种属内	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	GMS	28515320
种属内	TIGIT	Q495A1	NECTIN2	Homo sapiens	Q92692	X-Ray Diffraction	28515320

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TIGIT 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7414	TIGIT Protein, Human (HEK293, Fc)	Q495A1-1 (M22-P141)	≥95%
HY-P70624	TIGIT Protein, Human (HEK293, His)	Q495A1-1 (M22-P141)	≥95%
HY-P71363	TIGIT Protein, Human (HEK293, mFc)	Q495A1-1 (M22-P141)	≥95%
HY-P72418	TIGIT Protein, Human (HEK293, His-Avi)	Q495A1-1 (M22-P141)	≥95%
HY-P78216	TIGIT Protein, Human (Biotinylated, HEK293, His-Avi)	Q495A1-1 (M22-P141)	≥95%

关联疾病

疾病名称

别名

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-A0070A	Liothyronine	Activator	99.82%	是

目录号	产品名	作用方式	纯度	Phase
HY-P9986	Tiragolumab	Inhibitor	99.04%	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14524	TIGIT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990704	Rilvegostomig		/	否
HY-P990960	Lucorafusp alfa		/	否
HY-P990746	Lancastotug	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TIGIT	VGNC	VGNC:47374
Mus musculus	TIGIT	MGD	MGI:3642260
Felis catus	TIGIT	VGNC	VGNC:102853
Rattus norvegicus	TIGIT	RGD	RGD:1563191
Macaca mulatta	TIGIT	VGNC	VGNC:110333
Bos taurus	TIGIT	VGNC	VGNC:35868
Macaca fascicularis	TIGIT	NCBI	NCBI:102121588
Leporidae	TIGIT	NCBI
Others	TIGIT	NCBI

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TIGIT - T cell immunoreceptor with Ig and ITIM domains Gene

关于 TIGIT

功能概要

TIGIT 基因产物(1)

TIGIT 蛋白结构

TIGIT 蛋白互作信息

重组 TIGIT 蛋白

关联疾病

直系同源

热门区域

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TIGIT - T cell immunoreceptor with Ig and ITIM domains Gene

关于 TIGIT

功能概要

TIGIT 基因产物(1)

TIGIT 蛋白结构

TIGIT 蛋白互作信息

重组 TIGIT 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z