AAK1 - AP2 associated kinase 1 Gene

中文名称：AP2 相关激酶 1

种属: Homo sapiens

关于 AAK1

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶 SNF1 亚家族的成员。适配器相关蛋白复合物 2 (AP-2 复合物) 在受体介导的内吞作用期间发挥作用，触发网格蛋白组装、与膜结合受体相互作用，并募集内分泌辅助因子。编码的蛋白质与 AP-2 复合物的一个亚基相互作用并磷酸化，这促进了 AP-2 与膜结合受体中发现的分选信号的结合以及随后的受体内吞作用。其激酶活性受网格蛋白刺激。该激酶已被证明在调节网格蛋白介导的狂犬病病毒内吞作用、促进感染中发挥重要作用。这种激酶的抑制剂正在作为候选疗法进行研究，以破坏包括 SARS-CoV-2 在内的病毒进入靶细胞。它还参与哺乳动物 Notch 通路信号的正向调节。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2020 年 8 月]

This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating Infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Aug 2020]