TPX2 - TPX2 microtubule nucleation factor Gene

中文名称：TPX2 微管成核因子

种属: Homo sapiens

同用名: DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1

基因 ID: 22974 | 基因类型: protein coding

关于 TPX2

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,739,290-31,801,800 (from NCBI)

This gene has 2 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues.

功能概要

启用 importin-alpha 家族蛋白结合活性和蛋白激酶结合活性。参与激活蛋白激酶活性；微管细胞骨架组织；和微管解聚的负调节。位于细胞间桥；有丝分裂纺锤体;和核质。与主轴杆共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule Cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

TPX2 基因产物(1)

mRNA	Protein	Name
NM_012112.5	NP_036244.2	targeting protein for Xklp2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables importin-alpha family protein binding	IDA IDA: 通过直接分析推断	26165940	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	37728657	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14580337	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	14580337	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of protein kinase activity	IDA IDA: 通过直接分析推断	14580337	GOA
involved in microtubule nucleation	IDA IDA: 通过直接分析推断	26414402	GOA
involved in mitotic spindle assembly	IDA IDA: 通过直接分析推断	26165940	GOA
involved in negative regulation of microtubule depolymerization	IDA IDA: 通过直接分析推断	26414402	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in spindle	IDA IDA: 通过直接分析推断	37728657	GOA
colocalizes with spindle pole	IDA IDA: 通过直接分析推断	14718566	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPX2 蛋白结构

Aurora-A_bind

TPX2_importin

TPX2

0
200
400
600
747 a.a.

蛋白主名

其他名称

targeting protein for Xklp2

TPX2, microtubule-associated protein homolog

TPX2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TPX2	Q9ULW0	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	TPX2	Q9ULW0	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	TPX2	Q9ULW0	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	TPX2	Q9ULW0	HMMR	Homo sapiens	O75330	Anti Bait CoIP	22110403
Intra	TPX2	Q9ULW0	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	TPX2	Q9ULW0	AURKA	Homo sapiens	O14965	X-Ray Diffraction	14580337
Intra	TPX2	Q9ULW0	AURKA	Homo sapiens	O14965	Anti Bait CoIP	22110403
Intra	TPX2	Q9ULW0	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TPX2	Q9ULW0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TPX2	Q9ULW0	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	TPX2	Q9ULW0	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	TPX2	Q9ULW0	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	TPX2	Q9ULW0	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Capillary Leak Syndrome

Systemic Capillary Leak Syndrome	Clarkson Disease
Capillary Leak Syndrome With Monoclonal Gammopathy	Scls
Periodic Systemic Capillary Leak Syndrome	Capillary Hyperpermeability Syndrome
Idiopathic Capillary Leak Syndrome

Capillary Disease

Disease Of Capillaries

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-125956	Aurkin A	Inhibitor	≥98.0%	否
HY-168022	CAM2602		/	否
HY-158038	AurkA allosteric-IN-1	Inhibitor	/	否
HY-RS14959	TPX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TPX2	MGD	MGI:1919369
Rattus norvegicus	TPX2	RGD	RGD:1311894
Macaca mulatta	TPX2	VGNC	VGNC:78697
Canis familiaris	TPX2	VGNC	VGNC:47757
Bos taurus	TPX2	VGNC	VGNC:36266
Felis catus	TPX2	VGNC	VGNC:66489
Others	TPX2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TPX2 - TPX2 microtubule nucleation factor Gene

关于 TPX2

功能概要

TPX2 基因产物(1)

TPX2 蛋白结构

TPX2 蛋白互作信息

关联疾病

直系同源

热门区域

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TPX2 - TPX2 microtubule nucleation factor Gene

关于 TPX2

功能概要

TPX2 基因产物(1)

TPX2 蛋白结构

TPX2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

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Q

S

T

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