1. Gene
  2. Gak - cyclin G associated kinase Gene

Gak - cyclin G associated kinase Gene

中文名称:细胞周期蛋白G相关激酶

种属: Mus musculus

同用名: D130045N16Rik

基因 ID: 231580 | 基因类型: protein coding

关于 Gak

Chromosome 5: 108,717,277-108,777,621 reverse strand.GRCm39:CM000998.3

This gene has 13 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 7 phenotypes. Ubiquitous expression in colon adult (RPKM 34.6), large intestine adult (RPKM 29.7) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动网格蛋白结合活性和细胞周期蛋白结合活性。作用于多个过程的上游或内部,包括动物器官发育;网格蛋白涂层拆卸;和神经前体细胞增殖的正调节。预测位于高尔基体。预计在细胞质中有活性;细胞内膜结合细胞器;和囊泡。以多种结构表达,包括中枢神经系统;肝;和视网膜。与人类 GAK(细胞周期蛋白 G 相关激酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable clathrin binding activity and cyclin binding activity. Acts upstream of or within several processes, including animal organ development; clathrin coat disassembly; and positive regulation of neural precursor cell proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in several structures, including central nervous system; liver; and retina. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gak 基因产物(6)

mRNA Protein Name
NM_001359923.1 NP_001346852.1 cyclin-G-associated kinase isoform 5
NM_001282052.1 NP_001268981.1 cyclin-G-associated kinase isoform 3
NM_001359924.1 NP_001346853.1 cyclin-G-associated kinase isoform 2
NM_153569.2 NP_705797.1 cyclin-G-associated kinase isoform 1
NM_001282051.1 NP_001268980.1 cyclin-G-associated kinase isoform 2
NM_001359922.1 NP_001346851.1 cyclin-G-associated kinase isoform 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15752756 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Golgi organization IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within clathrin coat disassembly IGI
IGI: 通过遗传相互作用推断
20160091 MGI
acts upstream of or within clathrin-dependent endocytosis IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within epidermal cell differentiation IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within epithelial cell development IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within establishment of skin barrier IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within intrahepatic bile duct development IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within neuroepithelial cell differentiation IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
18434600 MGI
acts upstream of or within stem cell differentiation IMP
IMP: 通过突变表型推断
18434600 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Gak 蛋白结构

STKc_GAK

STKc_GAK: cd14036 (38 - 319)

PTP_GAK

PTP_GAK: cd14564 (397 - 559)

PTEN_C2

PTEN_C2: pfam10409 (567 - 705)

PHA03247

PHA03247: cl33720 (712 - 1168)

DnaJ

DnaJ: cd06257 (1252 - 1297)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1305 a.a.
蛋白主名 其他名称

cyclin-G-associated kinase

Gak 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Gak Q99KY4 Il12rb2 Mus musculus P97378
Anti Tag CoIP
17937931
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gak NCBI NCBI:2580
Macaca fascicularis Gak NCBI NCBI:102115623