FBXL7 - F-box and leucine rich repeat protein 7 Gene

中文名称：F-box 和富亮氨酸的重复蛋白 7

种属: Homo sapiens

同用名: FBL6; FBL7

基因 ID: 23194 | 基因类型: protein coding

关于 FBXL7

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:15,500,180-15,939,793 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 15 paralogues. Ubiquitous expression in endometrium (RPKM 6.3), adrenal (RPKM 5.3) and 22 other tissues.

功能概要

该基因编码 F-box 蛋白家族的一个成员，其特征是具有 42-48 个氨基酸基序，即 F-box，它与 S 期激酶相关蛋白 1 (Skp1) 蛋白结合。 F-box 蛋白构成称为 SCF (SKP1-Cul1-F-box) 的 E3 泛素蛋白连接酶的四个亚基之一，它在蛋白质的磷酸化依赖性泛素化中发挥作用。 F-box 蛋白根据蛋白质中的其他结构域分为 3 个亚家族：也具有 WD-40 结构域的 F-box 蛋白 (Fbws 亚家族) 、也具有富含亮氨酸重复序列的 F-box 蛋白 (Fbls 亚家族) ) 和包含其他基序或缺乏已知蛋白质相互作用域的 F-box 蛋白 (Fbxs 亚家族) 。该基因编码的蛋白质属于 Fbls 亚家族。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 5 月]

This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the Other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain Other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

FBXL7 基因产物(2)

mRNA	Protein	Name
NM_001278317.2	NP_001265246.1	F-box/LRR-repeat protein 7 isoform 2
NM_012304.5	NP_036436.1	F-box/LRR-repeat protein 7 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25778398	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	25778398	GOA
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	28218735	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	25778398	GOA
involved in protein polyubiquitination	IMP IMP: 通过突变表型推断	28218735	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	25778398	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FBXL7 蛋白结构

F-box-like

LRR_6

0
100
200
300
400
491 a.a.

蛋白主名

其他名称

F-box/LRR-repeat protein 7

F-box protein Fbl7

FBXL7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FBXL7	Q9UJT9	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
种属内	FBXL7	Q9UJT9	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
种属内	FBXL7	Q9UJT9	TBC1D5	Homo sapiens	Q92609	Y2H Array	32296183
种属内	FBXL7	Q9UJT9	TBC1D5	Homo sapiens	Q92609	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D	Hmn Iid
Dhmn2d	Distal Hereditary Motor Neuronopathy Type 2d
Distal Hereditary Motor Neuropathy Type Iid	Neuronopathy, Distal Hereditary Motor, Type 2d
Neuropathy, Distal Hereditary Motor, Type Iid	Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant
Distal Spinal Muscular Atrophy With Calf Predominance	Neuronopathy, Distal Hereditary Motor, 2d
Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant	Dhmn Iid
Neuropathy, Motor, Distal, Hereditary, Type 2d

Hennekam Syndrome

Hennekam Lymphangiectasia Lymphedema Syndrome	Hennekam Lymphangiectasia-Lymphedema Syndrome
Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome	Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome
Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome	Lymphangiectasies And Lymphedema Hennekam Type
Generalized Lymphatic Dysplasia	Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04794	FBXL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	FBXL7	VGNC	VGNC:97435
Bos taurus	FBXL7	VGNC	VGNC:52778
Canis familiaris	FBXL7	VGNC	VGNC:50891
Rattus norvegicus	FBXL7	RGD	RGD:1305813
Macaca mulatta	FBXL7	VGNC	VGNC:81409
Mus musculus	FBXL7	MGD	MGI:3052506

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4