2. Gene
  3. ARHGAP45 - Rho GTPase activating protein 45 Gene

ARHGAP45 - Rho GTPase activating protein 45 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 45

种属: Homo sapiens

同用名: HA-1; HMHA1; HLA-HA1

基因 ID: 23526 | 基因类型: protein coding

关于 ARHGAP45

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,065,959-1,086,628 (from NCBI)

This gene has 16 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in spleen (RPKM 23.6), bone marrow (RPKM 17.0) and 22 other tissues.

功能概要

预测启用 GTPase 激活剂活动。预测参与 GTPase 活性的激活。位于膜内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP45 基因产物(5)

mRNA Protein Name
NM_001258328.4 NP_001245257.1 rho GTPase-activating protein 45 isoform 2 precursor
NM_001282334.2 NP_001269263.1 rho GTPase-activating protein 45 isoform 3
NM_001282335.3 NP_001269264.1 rho GTPase-activating protein 45 isoform 4
NM_001321232.2 NP_001308161.1 rho GTPase-activating protein 45 isoform 5
NM_012292.5 NP_036424.2 rho GTPase-activating protein 45 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24086303 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP45 蛋白结构

RhoGAP

RhoGAP: RhoGAP domain (775 - 945)

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  • 1000
  • 1136 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 45

histocompatibility (minor) HA-1

ARHGAP45 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARHGAP45 Q92619 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
种属内
ARHGAP45 Q92619 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
种属内
ARHGAP45 Q92619 GMIP Homo sapiens Q9P107
Validated Y2H
32296183
种属内
ARHGAP45 Q92619 GMIP Homo sapiens Q9P107
Y2H Array
32296183
种属内
ARHGAP45 Q92619 GMIP Homo sapiens Q9P107
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
ARHGAP45 Q92619 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
种属内
ARHGAP45 Q92619 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
种属内
ARHGAP45 Q92619 RAC1 Homo sapiens P63000
FACS
24086303
种属内
ARHGAP45 Q92619 RAC1 Homo sapiens P63000
Confocal
24086303
种属内
ARHGAP45 Q92619 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
ARHGAP45 Q92619 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
ARHGAP45 Q92619 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
种属内
ARHGAP45 Q92619 ZUP1 Homo sapiens Q96AP4
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 ZUP1 Homo sapiens Q96AP4
Validated Y2H
32296183
种属内
ARHGAP45 Q92619 ZUP1 Homo sapiens Q96AP4
Y2H Array
32296183
种属内
ARHGAP45 Q92619 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
种属内
ARHGAP45 Q92619 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
种属内
ARHGAP45 Q92619 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Graft-Versus-Host Disease

Graft-Versus-Host Disease, Susceptibility To

Graft Versus Host Disease

GVHDS

Graft-Versus-Host Disease, Protection Against

Gvh

Graft-Vs-Host Disease

Gvhd - [Graft-Versus-Host Disease]

Graft-Versus-Host Reaction Or Disease

Gvh - [Graft-Versus-Host] Disease

Gvh - [Graft-Versus-Host] Reaction
Acute Graft Versus Host Disease

Acute Graft-Versus-Host Disease

Acute Gvhd

Acute Gvh Disease

Acute Gvhd - [Graft-Versus-Host Disease]
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Hematologic Cancer

Hematologic Neoplasm

Hematologic Neoplasms

Hematologic Malignancies

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00938 ARHGAP45 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ARHGAP45 VGNC VGNC:59894
Macaca mulatta ARHGAP45 VGNC VGNC:69847
Canis familiaris ARHGAP45 VGNC VGNC:38066
Rattus norvegicus ARHGAP45 RGD RGD:1308662
Bos taurus ARHGAP45 VGNC VGNC:59319
Mus musculus ARHGAP45 MGD MGI:1917969
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