2. Gene
  3. Sarm1 - sterile alpha and HEAT/Armadillo motif containing 1 Gene

Sarm1 - sterile alpha and HEAT/Armadillo motif containing 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Sarm; MyD885; A830091I15Rik

基因 ID: 237868 | 基因类型: protein coding

关于 Sarm1

功能概要

Enables NAD+ nucleosidase activity. Involved in NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Acts upstream of or within regulation of apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrion. Is extrinsic component of mitochondrial outer membrane. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Sarm1 基因产物(2)

mRNA Protein Name
NM_001168521.1 NP_001161993.1 NAD(+) hydrolase SARM1 isoform 1
NM_172795.3 NP_766383.2 NAD(+) hydrolase SARM1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+ nucleosidase activity IDA
IDA: 通过直接分析推断
28334607 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17724133 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NAD catabolic process IDA
IDA: 通过直接分析推断
28334607 MGI
involved in NAD catabolic process IMP
IMP: 通过突变表型推断
27735788 MGI
involved in nervous system process IMP
IMP: 通过突变表型推断
17724133 MGI
involved in protein localization to mitochondrion IMP
IMP: 通过突变表型推断
17724133 MGI
involved in regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
21555464 MGI
acts upstream of or within regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17724133 MGI
involved in regulation of synapse pruning IDA
IDA: 通过直接分析推断
22678360 MGI
involved in regulation of synapse pruning IMP
IMP: 通过突变表型推断
22678360 MGI
acts upstream of or within response to glucose IMP
IMP: 通过突变表型推断
17724133 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cell surface IDA
IDA: 通过直接分析推断
17804407 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17724133 MGI
located in dendrite IMP
IMP: 通过突变表型推断
21555464 MGI
located in microtubule IDA
IDA: 通过直接分析推断
17724133 MGI
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
17724133 MGI
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
17724133 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
17724133 MGI
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
22678360 MGI
is active in neuromuscular junction IMP
IMP: 通过突变表型推断
22678360 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
17804407 MGI
located in synapse IDA
IDA: 通过直接分析推断
21555464 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

NAD(+) hydrolase SARM1

NADP(+) hydrolase SARM1

NADase SARM1

Tir-1 homolog

sterile alpha and TIR motif containing 1

sterile alpha and TIR motif-containing protein 1

Sarm1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Sarm1 Q6PDS3 GHITM Homo sapiens Q9H3K2
Anti Tag CoIP
21903422
Cross Sarm1 Q6PDS3 NLRX1 Homo sapiens Q86UT6
Anti Tag CoIP
21903422
Cross Sarm1 Q6PDS3 IRAK2 Homo sapiens O43187
Anti Tag CoIP
21903422
Cross Sarm1 Q6PDS3 STT3A Homo sapiens P46977
Anti Tag CoIP
21903422
Cross Sarm1 Q6PDS3 CCDC47 Homo sapiens Q96A33
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0985 Phenazopyridine hydrochloride Antagonist 99.84% 否
HY-B0985A Phenazopyridine Antagonist 99.93% 否
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-129522 Sulfo-ara-F-NMN Activator 99.36% 否
HY-W021879 DSRM-3716 99.86% 否
HY-145917 SARM1-IN-2 Inhibitor 99.34% 否
HY-Z0816 Dehydronitrosonisoldipine Antagonist ≥98.0% 否
HY-112257 S-23 Modulator 99.93% 否
HY-161918 SARM1-IN-3 Inhibitor / 否
HY-RS12446 SARM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W008341 5-Chloroisoquinoline Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sarm1 NCBI NCBI:23098
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