Tlr2 - toll-like receptor 2 Gene

中文名称：Toll样受体 2

种属: Mus musculus

同用名: Ly105

关于 Tlr2

功能概要

该基因编码的蛋白可启动脂磷壁酸结合活性和肽结合活性。参与多个过程，包括细胞成分组织的负调节；细胞因子产生的正调节；和大分子生物合成过程的正调控。作用于多个过程的上游或内部，包括模式识别受体信号通路；调节细胞因子的产生；和对细菌的反应。位于质膜外侧。 Toll 样受体 2-Toll 样受体 6 蛋白复合物的一部分。以多种结构表达，包括大脑；早期胚胎；泌尿生殖系统；直觉;和免疫系统。该基因的人类直系同源物与多种疾病有关，包括自身免疫性疾病（多种）；皮炎（多发性）；胃肠系统癌症（多发性）；肺部疾病（多发）；和鼻炎（多种）。与人类 TLR2（toll 样受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like Receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (Toll Like Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]