Esr2 - estrogen receptor 2 Gene

中文名称：雌激素受体 2

种属: Rattus norvegicus

同用名: Erb2; ERbeta; ER-beta

关于 Esr2

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录激活剂活性、RNA 聚合酶 II 特异性；雌激素结合活性；和类固醇结合活性。参与多个过程，包括动物器官发育；调节神经元死亡；和对类固醇激素的反应。位于几种细胞成分中，包括线粒体；核周;和细胞质的核周区。蛋白质-DNA 复合物的一部分。用于研究多种疾病，包括高血压（多种）；肥胖;腹膜炎;原位前列腺癌；和短暂性脑缺血。哮喘的生物标志物；脑缺血;结肠炎;膀胱炎;和骨质疏松症。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；自身免疫性疾病（多种）；尿道下裂;神经退行性疾病（多种）；和卵巢发育不全 8。与人类 ESR2（雌激素受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Located in several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (Estrogen Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]