Adora2a - adenosine A2a receptor Gene

中文名称：腺苷 A2 a受体

种属: Rattus norvegicus

同用名: A2ar; ADENO; Adora2l1

基因 ID: 25369 | 基因类型: protein coding

关于 Adora2a

Primary_assembly 20: 13,315,853-13,333,386 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 263 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Brain (RPKM 73.9), Lung (RPKM 63.2) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联腺苷受体活性； α-肌动蛋白结合活性；和 5 型代谢型谷氨酸受体结合活性。参与多个过程，包括G蛋白偶联受体信号通路；化学突触传递；和分泌调节。位于几个细胞组件中，包括轴膜；突触后密度；和突触膜。在谷氨酸能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。与中间丝共定位。用于研究肺部疾病。该基因的人类直系同源物与哮喘有关。与人类 ADORA2A（腺苷 A2a 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled Adenosine Receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axolemma; postsynaptic density; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with intermediate filament. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2a 基因产物(2)

mRNA	Protein	Name
NM_053294.5	NP_445746.3	adenosine receptor A2a A2AR
NM_001357942.1	NP_001344871.1	adenosine receptor A2a uORF5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled adenosine receptor activity	IDA IDA: 通过直接分析推断	12590138	RGD
enables alpha-actinin binding	IDA IDA: 通过直接分析推断	12837758	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	16617164	RGD
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	16481441	RGD
enables type 5 metabotropic glutamate receptor binding	IPI IPI: 通过物理相互作用推断	12189203	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled adenosine receptor signaling pathway	IDA IDA: 通过直接分析推断	12590138	RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	16478979	RGD
involved in astrocyte activation	IMP IMP: 通过突变表型推断	12838511	RGD
involved in eating behavior	IMP IMP: 通过突变表型推断	12827647	RGD
involved in excitatory postsynaptic potential	IDA IDA: 通过直接分析推断	16644907	RGD
involved in locomotory behavior	IMP IMP: 通过突变表型推断	12827647	RGD
involved in membrane depolarization	IMP IMP: 通过突变表型推断	16644907	RGD
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	16617164	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	15211592	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	15211592	RGD
involved in negative regulation of protein kinase activity	IDA IDA: 通过直接分析推断	12590138	RGD
involved in negative regulation of vascular permeability	IMP IMP: 通过突变表型推断	16815983	RGD
involved in neuron projection morphogenesis	IDA IDA: 通过直接分析推断	16617164	RGD
involved in neuron projection morphogenesis	IMP IMP: 通过突变表型推断	12727227	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	12590138	RGD
involved in positive regulation of acetylcholine secretion, neurotransmission	IMP IMP: 通过突变表型推断	12679375	RGD
involved in positive regulation of circadian sleep/wake cycle, sleep	IDA IDA: 通过直接分析推断	16109808	RGD
involved in positive regulation of glutamate secretion	IDA IDA: 通过直接分析推断	16481441	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: 通过突变表型推断	14596853	RGD
involved in positive regulation of protein secretion	IDA IDA: 通过直接分析推断	14742743	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: 通过直接分析推断	16481441	RGD
involved in positive regulation of urine volume	IMP IMP: 通过突变表型推断	10070140	RGD
involved in prepulse inhibition	IMP IMP: 通过突变表型推断	12827647	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: 通过实验结果推断	15659214	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	15659214	RGD
involved in presynaptic modulation of chemical synaptic transmission	IEP IEP: 通过表达模式推断	15659214	RGD
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12189203	RGD
involved in regulation of calcium ion transport	IMP IMP: 通过突变表型推断	15297571	RGD
involved in regulation of mitochondrial membrane potential	IDA IDA: 通过直接分析推断	15211592	RGD
involved in regulation of norepinephrine secretion	IMP IMP: 通过突变表型推断	16539684	RGD
involved in response to alkaloid	IMP IMP: 通过突变表型推断	16684876	RGD
involved in response to caffeine	IDA IDA: 通过直接分析推断	16481441	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	17853654	RGD
involved in synaptic transmission, cholinergic	IMP IMP: 通过突变表型推断	15297571	RGD
involved in synaptic transmission, glutamatergic	IDA IDA: 通过直接分析推断	16644907	RGD
involved in vasodilation	IMP IMP: 通过突变表型推断	10070140	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in asymmetric synapse	IDA IDA: 通过直接分析推断	16481441	RGD
located in axolemma	IDA IDA: 通过直接分析推断	16481441	RGD
located in axon	IDA IDA: 通过直接分析推断	16952160	RGD
located in dendrite	IDA IDA: 通过直接分析推断	16952160	RGD
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	15659214	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	15659214	RGD
located in intermediate filament	IDA IDA: 通过直接分析推断	16644907	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	16644907	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	23994616	RGD
is active in postsynaptic membrane	IDA IDA: 通过直接分析推断	16952160	RGD
located in postsynaptic membrane	IDA IDA: 通过直接分析推断	16481441	RGD
located in presynaptic active zone	IDA IDA: 通过直接分析推断	16481441	RGD
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	16952160	RGD
located in presynaptic membrane	IDA IDA: 通过直接分析推断	16481441	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Adora2a 蛋白结构

7tmA_Adenosine_R_A2A

0
100
200
300
410 a.a.

蛋白主名

其他名称

adenosine receptor A2a

Adenosine A2a-receptor

Adora2a 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Adora2a	P30543	Cnr1	Rattus norvegicus	P20272	Anti Bait CoIP	17356572
Cross	Adora2a	P30543	Tsnax	Mus musculus	Q9QZE7	Pull Down	16617164
Cross	Adora2a	P30543	Tsnax	Mus musculus	Q9QZE7	Y2H	16617164
Cross	Adora2a	P30543	Tsnax	Mus musculus	Q9QZE7	Confocal	16617164

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00394	ADORA2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00395	Adora2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00396	Adora2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Adora2a	NCBI	NCBI:135

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Adora2a - adenosine A2a receptor Gene

关于 Adora2a

功能概要

Adora2a 基因产物(2)

Adora2a 蛋白结构

Adora2a 蛋白互作信息

直系同源

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Adora2a - adenosine A2a receptor Gene

关于 Adora2a

功能概要

Adora2a 基因产物(2)

Adora2a 蛋白结构

Adora2a 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z