GABPA - GA binding protein transcription factor subunit alpha Gene

中文名称：GA 结合蛋白转录因子亚基α

种属: Homo sapiens

同用名: NFT2; NRF2; NRF2A; E4TF1A; E4TF1-60; RCH04A07

关于 GABPA

功能概要

该基因编码三个 GA 结合蛋白转录因子亚基之一，该亚基起 DNA 结合亚基的作用。由于该亚基与编码核呼吸因子 2 基因的亚基具有同一性，因此它可能参与细胞色素氧化酶表达的激活和线粒体功能的核控制。该亚基还与构成转录因子 E4TF1 的亚基相同，后者负责腺病毒 E4 基因的表达。由于其染色体定位和与其他多肽形成异二聚体的能力，该基因可能在唐氏综合症表型中发挥作用。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2010 年 10 月]

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with Other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]