2. Gene
  3. AGO1 - argonaute RISC component 1 Gene

AGO1 - argonaute RISC component 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：argonaute RISC 组件 1

种属: Homo sapiens

同用名: Q99; EIF2C; hAgo1; EIF2C1; GERP95

基因 ID: 26523 | 基因类型: protein coding

关于 AGO1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,869,761-35,930,532 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 4.5), brain (RPKM 3.9) and 25 other tissues.

功能概要

该基因编码 argonaute 蛋白家族的一员，该蛋白与小 RNA 相关，在 RNA 干扰 (RNAi) 和 RNA 沉默中具有重要作用。这种蛋白质与 MicroRNA (miRNA) 或小干扰 RNA (siRNA) 结合，并抑制与其互补的 mRNA 的翻译。它还参与与结合的短反基因 RNA (agRNA) 互补的启动子区域的转录基因沉默 (TGS) ，以及 miRNA 结合的 mRNA 靶标的降解。已发现该基因编码不同亚型的可变剪接转录物变体。最近的一项研究表明该基因是真正的终止密码子通读目标，并且其 mRNA 可以通过使用替代的框内翻译终止密码子来产生额外的 C 末端扩展同种型。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to MicroRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

AGO1 基因产物(3)

mRNA Protein Name
NM_001317122.2 NP_001304051.1 protein argonaute-1 isoform 1x
NM_001317123.2 NP_001304052.1 protein argonaute-1 isoform 2
NM_012199.5 NP_036331.1 protein argonaute-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
23809764 GOA
NOT enables RNA endonuclease activity IDA
IDA: 通过直接分析推断
23809764 GOA
enables RNA polymerase II complex binding IDA
IDA: 通过直接分析推断
25336585 GOA
enables core promoter sequence-specific DNA binding IMP
IMP: 通过突变表型推断
25336585 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
19966796 GOA
enables miRNA binding IDA
IDA: 通过直接分析推断
15260970 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12526743 GOA
enables single-stranded RNA binding IDA
IDA: 通过直接分析推断
19966796 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RISC complex assembly IDA
IDA: 通过直接分析推断
19966796 GOA
involved in RNA secondary structure unwinding IDA
IDA: 通过直接分析推断
19966796 GOA
involved in RNA secondary structure unwinding IMP
IMP: 通过突变表型推断
22795694 GOA
involved in miRNA processing IMP
IMP: 通过突变表型推断
22795694 GOA
involved in miRNA-mediated gene silencing by inhibition of translation IDA
IDA: 通过直接分析推断
18771919 GOA
NOT involved in miRNA-mediated gene silencing by mRNA destabilization IDA
IDA: 通过直接分析推断
15260970 GOA
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
23426184 GOA
involved in nuclear-transcribed mRNA catabolic process IDA
IDA: 通过直接分析推断
18771919 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25336585 GOA
involved in pre-miRNA processing IDA
IDA: 通过直接分析推断
19966796 GOA
NOT involved in siRNA-mediated gene silencing by mRNA destabilization IDA
IDA: 通过直接分析推断
15260970 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RISC complex IDA
IDA: 通过直接分析推断
15260970 GOA
part of RISC-loading complex IDA
IDA: 通过直接分析推断
19966796 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15260970 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGO1 蛋白结构

ArgoL1

ArgoL1: Argonaute linker 1 domain (173 - 225)

PAZ

PAZ: PAZ domain (233 - 368)

Piwi

Piwi: Piwi domain (515 - 815)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 857 a.a.
蛋白主名 其他名称

protein argonaute-1

Golgi Endoplasmic Reticulum protein 95 kDa

重组 AGO1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74424 AGO1 Protein, Human (sf9, His) Q9UL18 (M1-A857) ≥95%

关联疾病

疾病名称 别名
Tremor

Medicament-Induced Tremor

Medication-Induced Postural Tremor
Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type

CHH

Mckusick Type Metaphyseal Chondrodysplasia

Metaphyseal Dysplasia Without Hypotrichosis

Cartilage Hair Hypoplasia Like Syndrome

Metaphyseal Chondrodysplasia Mckusick Type

Chhv

Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

Cartilage-Hair Syndrome

Mckusick'S Metaphyseal Chondrodysplasia Syndrome

Metaphyseal Chondrodysplasia, Recessive Type

Autosomal Recessive Metaphyseal Chondrodysplasia
Cervical Non-Keratinizing Squamous Cell Carcinoma
Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18

RP7

Retinitis Pigmentosa 7, Digenic Form

Retinitis Pigmentosa 7 And Digenic Form

Retinitis Pigmentosa 7, Digenic

LCA18

Retinitis Pigmentosa 7 Digenic
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00452 AGO1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AGO1 RGD RGD:1304619
Felis catus AGO1 VGNC VGNC:107483
Bos taurus AGO1 VGNC VGNC:25732
Macaca mulatta AGO1 VGNC VGNC:81346
Mus musculus AGO1 MGD MGI:2446630
Canis familiaris AGO1 VGNC VGNC:54192
Others AGO1 NCBI
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