2. Gene
  3. Il18 - interleukin 18 Gene

Il18 - interleukin 18 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: IL-18; IL-1 gamma

基因 ID: 29197 | 基因类型: protein coding

关于 Il18

功能概要

Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract Infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

Il18 基因产物(1)

mRNA Protein Name
NM_019165.2 NP_062038.2 interleukin-18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12034039 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
12490070 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
12684057 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
11739527 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
18320471 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: 通过表达模式推断
18165223 RGD
involved in cellular response to peptide hormone stimulus IMP
IMP: 通过突变表型推断
12490070 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
18547159 RGD
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
18547159 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IDA
IDA: 通过直接分析推断
19853379 RGD
involved in digestive tract morphogenesis IEP
IEP: 通过表达模式推断
21088234 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
24412291 RGD
involved in lung development IEP
IEP: 通过表达模式推断
18952566 RGD
involved in negative regulation of neutrophil apoptotic process IMP
IMP: 通过突变表型推断
20844839 RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
22001439 RGD
involved in osteoblast differentiation IEP
IEP: 通过表达模式推断
18165223 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
22001439 RGD
involved in positive regulation of blood vessel remodeling IDA
IDA: 通过直接分析推断
19717152 RGD
involved in positive regulation of chemokine production IMP
IMP: 通过突变表型推断
19497959 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: 通过直接分析推断
20644901 RGD
involved in positive regulation of hepatocyte proliferation IDA
IDA: 通过直接分析推断
24412291 RGD
involved in positive regulation of interleukin-1 beta production IEP
IEP: 通过表达模式推断
17623049 RGD
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
18547159 RGD
involved in positive regulation of male germ cell proliferation IDA
IDA: 通过直接分析推断
16002206 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17188500 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
22636674 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
22636674 RGD
involved in positive regulation of superoxide anion generation IMP
IMP: 通过突变表型推断
19497959 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
17623049 RGD
involved in positive regulation of vascular permeability IMP
IMP: 通过突变表型推断
11739527 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
19672068 RGD
involved in response to hypoxia IMP
IMP: 通过突变表型推断
12122053 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
11086064 RGD
involved in sleep IDA
IDA: 通过直接分析推断
11506998 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12032269 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
16002206 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-18

IFN-gamma-inducing factor

interferon gamma-inducing factor

interleukin-1 gamma

重组 Il18 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7210 IL-18 Protein, Rat P97636-1 (H37-S194) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13205 Belnacasan Inhibitor 99.99% Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99491 Camoteskimab Inhibitor 98.41% Phase 1
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16990 Ac-YVAD-cmk Inhibitor 98.94% 否
HY-101092 QS-21 Activator 99.67% 否
HY-19676 Pralnacasan Inhibitor 99.83% 否
HY-156413 NLRP3 agonist 1 Agonist 99.01% 否
HY-150742 ODN 2336 Agonist 90.74% 否
HY-W176629 Hydrocotarnine Inhibitor 99.59% 否
HY-147660 IMMH001 Agonist 98.10% 否
HY-102019 NSC61610 Inhibitor 99.50% 否
HY-160793 NSC80734 Inhibitor 98.08% 否
HY-164426 HEI3090 Activator 99.04% 否
HY-123879 BAA473 98.93% 否
HY-149478 JT002 Inhibitor / 否
HY-158024A (S)-NDT-19795 Inhibitor / 否
HY-111662 Fc 11a-2 Inhibitor / 否
HY-150742A ODN 2336 sodium 90.74% 否
HY-RS06708 IL18 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06710 IL18R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-119337 CE-2072 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il18 NCBI NCBI:3606
Canis lupus familiaris Il18 NCBI
Mus musculus Il18 NCBI NCBI:16173
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