Oprl1 - opioid related nociceptin receptor 1 Gene

中文名称：阿片类药物相关伤害感受素受体 1

种属: Rattus norvegicus

同用名: KOR3; OFQR; ORL1; Oprl; XOR1; KOR-3; LC132; MOR-C

关于 Oprl1

功能概要

由该基因编码的蛋白质是 7 个跨膜 G 蛋白偶联受体家族的成员，作为内源性阿片类药物相关神经肽痛敏肽/孤啡肽 FQ 的受体发挥作用。这种受体-配体系统调节多种生物学功能和神经行为，包括应激反应和焦虑行为、学习和记忆、运动活动以及炎症和免疫反应。已发现该基因的可变剪接转录物变体。最近的一项研究为该基因的翻译通读提供了证据，并通过使用替代的框内翻译终止密码子表达了额外的 C 末端扩展同种型。 [RefSeq 提供，2017 年 12 月]

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]